503272-01-3Relevant articles and documents
Discovery and pharmacological profile of new 1H-indazole-3-carboxamide and 2H-pyrrolo[3,4-c]quinoline derivatives as selective serotonin 4 receptor ligands
Furlotti, Guido,Alisi, Maria Alessandra,Apicella, Claudia,Capezzone De Joannon, Alessandra,Cazzolla, Nicola,Costi, Roberta,Cuzzucoli Crucitti, Giuliana,Garrone, Beatrice,Iacovo, Alberto,Magarò, Gabriele,Mangano, Giorgina,Miele, Gaetano,Ombrato, Rosella,Pescatori, Luca,Polenzani, Lorenzo,Rosi, Federica,Vitiello, Marco,Di Santo, Roberto
, p. 9446 - 9466 (2013/01/16)
Since the discovery of the serotonin 4 receptor (5-HT4R), a large number of receptor ligands have been studied. The safety concerns and the lack of market success of these ligands have mainly been attributed to their lack of selectivity. In thi
Synthesis of 4-oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid ethyl ester and its isomer 1-oxo-2,9-dihydro-1H-β-carboline-4-carboxylic acid ethyl ester
Bergman, Jan,Rehn, Stanley
, p. 9179 - 9185 (2007/10/03)
4-Oxo-4,5-dihydro-3H-pyrrolo[2,3-c]quinoline-1-carboxylic acid ethyl ester was obtained when TosMIC was reacted with 3-methylene-oxindole acetic acid ethyl ester. An alternative synthesis to this pyrroloquinolone was performed via a reduction of a 2,3,4-trisubstituted pyrrole obtained in turn by treatment of a vinyl sulfone with ethyl isocyanoacetate under basic conditions. A β-carboline, isomeric with the pyrroloquinolone, was synthesised utilizing a tosylimine.
