5034-68-4Relevant articles and documents
Study of alkaloids of the Siberian and Altai flora 9. Synthesis of amino derivatives of elatidine
Ganbaatar,Osadchii,Shults,Tolstikov
, p. 2290 - 2294 (2002)
New secondary-tertiary diamines were prepared from elatidal imines with primary amino alcohols, derivatives of natural amino acids of the S-series. N-Methylation of the diamines yielded bi-tertiary diamines unable to undergo quaternization with MeI due to
Two modes of asymmetric polymerization of phenylacetylenes having an L -amino alcohol residue and two hydroxy groups
Jia, Hongge,Li, Jun,Zang, Yu,Aoki, Toshiki,Teraguchi, Masahiro,Kaneko, Takashi
, p. 5134 - 5143 (2013/01/15)
Four novel chiral phenylacetylenes having an L-amino alcohol residue and two hydroxymethyl groups were synthesized and polymerized by an achiral catalyst ((nbd)Rh+[η6-(C6H5)B -(C6H5)3]) or a chiral catalytic system ([Rh(nbd)Cl]2/(S)- or (R)-phenylethylamine ((S)- or (R)-PEA)). The two resulting polymers having an L-valinol or L-phenylalaninol residue showed Cotton effects at wavelengths around 430 nm. This observation indicated that they had an excess of one-handed helical backbones. Positive and negative Cotton effects were observed only for the polymers having an L-valinol residue produced by using (R)- and (S)-PEA as a cocatalyst, respectively, although the monomer had the same chirality. Even when the achiral catalyst was used, the two resulting polymers having an L-valinol or L-phenylalaninol residue showed Cotton effects despite the long distance between the chiral groups and the main chain. We have found the first example of a new type of chiral monomer, that is, a chiral phenylacetylene monomer having an L-amino alcohol residue and two hydroxy groups that was suitable for both modes of asymmetric polymerization, that is, the helix-sense-selective polymerization (HSSP) with the chiral catalytic system and the asymmetric-induced polymerization (AIP) with the achiral catalyst. The other two monomers having L-alaninol and L-tyrosinol were found to be unsuitable to neither HSSP nor AIP because of their polymers' low solubility.
Use of Syk Tyrosine Kinase Inhibitors for the Treatment of Cell Proliferative Disorders
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Page/Page column 7, (2009/12/24)
The invention relates to polyalkylene glycol compounds and their use in treating cell proliferative disorders, more specifically Syk tyrosine kinase-mediated disorders.