50344-83-7Relevant articles and documents
The synthesis of o nitrobenzaldehyde d 1 by a modified brown subba row reduction. A simple route to formyl deuteration
Filby,Gunther
, p. 321 - 324 (1973)
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Method for preparing deuterated aldehyde compound by using halomethyl compound as raw material
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Paragraph 0044-0045; 0047-0048, (2018/09/08)
The invention provides a method for preparing deuterated aldehyde compound by using halomethyl compound as a raw material. The method comprises the following steps that in solvent and D2O mixed liquidwith a pyridine compound, the halomethyl compound is added; reaction is performed at 0 to 100 DEG C; then, a nitrosobenzene type compound is added for continuous reaction; finally, reaction liquid issubjected to acidification to obtain a target product. The method has the advantages that the used raw materials are cheap and can be easily obtained; expensive reagents or heavy metal raw materialsare not needed; the reaction conditions are simple; the severe conditions such as high temperature are not needed; the cost of the preparation method is low; the operation is simple; the deuterated rate is high and can reach 97 percent; the target product can be easily purified; the yield is high and reaches up to 95 percent. The substrates used by the method have wide applicability; various deuterated aldehyde compounds can be prepared.
Indole synthesis based on a modified koser reagent
Fra, Laura,Millán, Alba,Souto, José A.,Mu?iz, Kilian
, p. 7349 - 7353 (2014/07/21)
A new metal-free method for the rapid and productive preparation of indoles has been developed. This process is based on sterically congested hypervalent iodine compounds of the family of Koser reagents, and iodosobenzene in combination with 2,4,5-tris-isopropylbenzene sulfonic acid provides the highest yields and fastest reaction times. This reagent alone promotes the chemoselective oxidative cyclization of 2-amino styrenes to indoles in high yields under mild conditions. Convenient route to indole: A fast, productive, and operationally simple indole synthesis was developed.