503468-73-3Relevant articles and documents
8-Biarylchromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK)
Murr, Marine Desage-El,Cano, Celine,Golding, Bernard T.,Hardcastle, Ian R.,Hummersome, Marc,Frigerio, Mark,Curtin, Nicola J.,Menear, Keith,Richardson, Caroline,Smith, Graeme C.M.,Griffin, Roger J.
body text, p. 4885 - 4890 (2009/06/17)
The synthesis and biological evaluation of libraries of 8-biarylchromen-4-ones enabled the elucidation of structure-activity relationships for inhibition of the DNA-dependent protein kinase (DNA-PK), with 8-(3-(thiophen-2-yl)phenyl)chromen-4-one and 8-(3-(thiophen-3-yl)phenyl)chromen-4-one being especially potent inhibitors.
