5035-14-3Relevant articles and documents
Wrightiamines A and B, two new cytotoxic pregnane alkaloids from Wrightia javanica
Kawamoto, Souichi,Koyano, Takashi,Kowithayakorn, Thaworn,Fujimoto, Haruhiro,Okuyama, Emi,Hayashi, Masahiko,Komiyama, Kanki,Ishibashi, Masami
, p. 737 - 739 (2003)
Two new pregnane alkaloids, wrightiamines A (1) and B (2), were isolated from the extract of the tropical Apocynaceous plant Wrightia javanica collected in Thailand, and their structures were elucidated by spectral data. Wrightiamine B (2) was preparaed from 3β-hydroxy-5α-pregnan-20-one to establish the configuration of the C-20 position as S. Wrightiamine A (1) exhibited cytotoxic activity against vincristine-resistant murine leukemia P388 cells.