503590-28-1

Basic information

• Product Name: 2-Oxazolidinone, 4-phenyl-3-[[tris(1-methylethyl)silyl]ethynyl]-, (4R)-
• CAS NO: 503590-28-1
• Molecular Formula: C20H29NO2Si
• Molecular Weight: 343.541
• Mol File: 503590-28-1.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Oxazolidinone, 4-phenyl-3-[[tris(1-methylethyl)silyl]ethynyl]-, (4R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Oxazolidinone, 4-phenyl-3-[[tris(1-methylethyl)silyl]ethynyl]-, (4R)-(503590-28-1)
• EPA Substance Registry System: 2-Oxazolidinone, 4-phenyl-3-[[tris(1-methylethyl)silyl]ethynyl]-, (4R)-(503590-28-1)

Safety Data

• Hazardous Substances Data: 503590-28-1(Hazardous Substances Data)

Upstream product

• 111409-79-1 1-bromo-2-(triisopropylsilyl)acetylene 
• 38052-67-4 C₉H₉NO₂ 
• 89343-06-6 tris-iso-propylsilyl acetylene 
• 90319-52-1 (4R)-phenyl-2-oxazolidinone 

Downstream Products

• 503590-46-3 (R)-3-ethynyl-4-phenyl-1,3-oxazolidin-2-one 
• 1092383-22-6 (R)-1-(2-oxo-4-phenyloxazolidin-3-yl)-2-(triisopropylsilyl)ethane-1,2-dione 

Relevant articles and documents

Highly substituted 2-amido-furans from rh(ll)-catalyzed cyclopropenations of ynamides

Rh(II)-catalyzed cyclopropenations of ynamides are described. Although an actual amido-cyclopropene intermediate may not be involved, these reactions provide a facile entry to highly substituted 2-amido-furans, thereby formerly constituting a [3 + 2] cycloaddition. An application of these de novo 2-amido-furans In N-tethered intramolecular [4 + 2] cycloadditions is also illustrated, leading to dihydroindoles and tetrahydroqulnolines

Copper(II)-catalyzed amidations of alkynyl bromides as a general synthesis of ynamides and Z-enamides. An intramolecular amidation for the synthesis of macrocydic ynamides

A general and efficient method for the coupling of a wide range of amides with alkynyl bromides is described here. This novel amidation reaction involves a catalytic protocol using copper(II) sulfate-pentahydrate and 1,10-phenanthroline to direct the sp-C-N bond formation, leading to a structurally diverse array of ynamides including macrocyclic ynamides via an intramolecular amidation. Given the surging interest in ynamide chemistry, this atom economical synthesis of ynamides should invoke further attention from the synthetic organic community.

A copper-catalyzed C-N bond formation involving sp-hybridized carbons. A direct entry to chiral ynamides via N-alkynylation of amides

A copper-catalyzed new C-N bond formation involving a sp-hybridized carbon is described here leading to a facile entry for syntheses of chiral ynamides. This direct N-alkynylation of amides should have a significant impact on the future development of synthetic methodologies employing ynamides. Copyright