503610-44-4

Basic information

• Product Name: ROSUVASTATIN ACYL-B-D-GLUCURONIDE
• Synonyms: ROSUVASTATIN ACYL-B-D-GLUCURONIDE;RosuvastatinGlucuronide;Rosuvastatin Acyl--D-glucuronide;Rosuvastatin acyl-β-D-glucuronide ,98%;1-[(3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-(1-Methylethyl)-2-[Methyl(Methylsulfonyl)aMino]-5-pyriMidinyl]-3,5-dihydroxy-6-heptenoate]
• CAS NO: 503610-44-4
• Molecular Formula: C28H36FN3O12S
• Molecular Weight: 657.665
• Product Categories: Glucuronides;Metabolites;Aromatics;Chiral Reagents;Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 503610-44-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 110-116°C
• Boiling Point: 940.343°C at 760 mmHg
• Flash Point: 522.501°C
• Appearance: /
• Density: 1.547g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: -20°C Freezer
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 2.68±0.70(Predicted)
• CAS DataBase Reference: ROSUVASTATIN ACYL-B-D-GLUCURONIDE(CAS DataBase Reference)
• NIST Chemistry Reference: ROSUVASTATIN ACYL-B-D-GLUCURONIDE(503610-44-4)
• EPA Substance Registry System: ROSUVASTATIN ACYL-B-D-GLUCURONIDE(503610-44-4)

Safety Data

• Hazardous Substances Data: 503610-44-4(Hazardous Substances Data)

Usage

Description

ROSUVASTATIN ACYL-B-D-GLUCURONIDE is a metabolite of Rosuvastatin, which is a selective and competitive HMG-CoA reductase inhibitor. It is a pale yellow solid and plays a significant role in the metabolism and efficacy of the parent drug, Rosuvastatin.

Uses

Used in Pharmaceutical Industry:
ROSUVASTATIN ACYL-B-D-GLUCURONIDE is used as a metabolite for enhancing the therapeutic effects of Rosuvastatin. As a metabolite, it contributes to the overall cholesterol-lowering action of Rosuvastatin by inhibiting HMG-CoA reductase, the enzyme responsible for cholesterol synthesis in the liver.
Used in Research and Development:
In the field of research and development, ROSUVASTATIN ACYL-B-D-GLUCURONIDE is used for studying the metabolic pathways and pharmacokinetics of Rosuvastatin. This helps in understanding the drug's absorption, distribution, metabolism, and excretion, which are crucial for optimizing its therapeutic potential and minimizing side effects.
Used in Quality Control and Drug Analysis:
ROSUVASTATIN ACYL-B-D-GLUCURONIDE is also utilized in the quality control and analysis of Rosuvastatin-containing pharmaceutical products. Its presence and concentration in these products can be assessed to ensure their quality, efficacy, and safety for patients.

InChI:InChI=1/C28H36FN3O12S/c1-13(2)20-18(21(14-5-7-15(29)8-6-14)31-28(30-20)32(3)45(4,41)42)10-9-16(33)11-17(34)12-19(35)43-27-24(38)22(36)23(37)25(44-27)26(39)40/h5-10,13,16-17,22-25,27,33-34,36-38H,11-12H2,1-4H3,(H,39,40)/b10-9+/t16-,17-,22+,23+,24+,25?,27?/m1/s1