50376-43-7Relevant articles and documents
The Kinetics and Mechanism, and the Equilibrium Position as a Function of pH, of the Isomerisation of Naringin and the 4'-Rhamnoglucoside of 2',4,4',6'-Tetrahydroxychalcone
Miles, Christopher O.,Main, Lyndsay
, p. 195 - 198 (1988)
The pH-rate profile for the title reaction has been determined and accounted for in terms of contributions from the various ionised species.The effect of ionisation of a chalcone 4-OH group on rate of cyclisation is quantitatively accommodated for the first time.The rate data have been used to calculate the position of the equilibrium and its rate of attainment as a function of pH, and this information should be general value for optimising conditions for synthesis of 2',4,6'-trihydroxychalcones by ring-opening 4',5-dihydroxyflavones.