503809-63-0Relevant articles and documents
8-Aryl xanthines potent inhibitors of phosphodiesterase 5
Arnold, Ruth,Beer, David,Bhalay, Gurdip,Baettig, Urs,Collingwood, Stephen P,Craig, Sarah,Devereux, Nicholas,Dunstan, Andrew,Glen, Angela,Gomez, Sylvie,Haberthuer, Sandra,Howe, Trevor,Jelfs, Stephen,Moser, Heinz,Naef, Reto,Nicklin, Paul,Sandham, David,Stringer, Rowan,Turner, Katharine,Watson, Simon,Zurini, Mauro
, p. 2587 - 2590 (2002)
In clinical studies, several inhibitors of phosphodiesterase 5 (PDE5) have demonstrated utility in the treatment of erectile dysfunction. We describe herein a series of 8-aryl xanthine derivatives which function as potent PDE5 inhibitors with, in many cases, high levels of selectivity versus other PDE isoforms.