504-89-2Relevant articles and documents
Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane-5,6- diol against hepatitis C virus
Gadthula, Srinivas,Rawal, Ravindra K.,Sharon, Ashoke,Wu, Dong,Korba, Brent,Chu, Chung K.
supporting information; experimental part, p. 3982 - 3985 (2011/08/06)
An efficient method was developed for the synthesis of 6-exocyclic methylene carbocyclic intermediate 4. The Simmons-Smith cyclopropanation protocol was applied on the 6-exocyclic methylene of intermediate 4 and demonstrated its utility for the synthesis of novel class of a spiro-carbocyclic nucleoside analog 8. The titled compound 8 demonstrated a significant antiviral activity against HCV with EC50 values of 0.273 and 0.368 μM in genotypes 1A and 1B, respectively.