50402-56-7 Usage
Description
1,5-EDANS, also known as N-(5-(Dimethylamino)naphthalen-1-yl)ethylene-1,2-diamine, is a fluorescent reagent with a terminal amine for derivatization. It exhibits similar spectral properties to the naphthalenesulfonic acids and is characterized by its gray-yellow crystalline powder appearance. 1,5-EDANS has a maximum absorption at 335nm and a maximum emission at 493nm, with an extinction coefficient (ε x 10^-3) of 5.9.
Uses
Used in Analytical Chemistry:
1,5-EDANS is used as a fluorescent derivatization reagent for the detection and analysis of various compounds in analytical chemistry. Its application reason is due to its unique spectral properties, which allow for sensitive and selective detection of target molecules.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 1,5-EDANS is used as a fluorescent probe for studying the interactions between drugs and their target biomolecules. The application reason is its ability to provide valuable information on binding affinities, kinetics, and structural changes upon interaction.
Used in Environmental Monitoring:
1,5-EDANS is employed as a fluorescent tracer in environmental monitoring to detect and quantify pollutants and contaminants in water and soil samples. The application reason is its high sensitivity and specificity, which enable accurate detection of trace amounts of target analytes.
Used in Material Science:
In material science, 1,5-EDANS is used as a fluorescent label for the characterization of materials at the molecular level. The application reason is its ability to provide insights into the structure, dynamics, and interactions of materials, which is crucial for the development of new materials with desired properties.
Check Digit Verification of cas no
The CAS Registry Mumber 50402-56-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,0,4,0 and 2 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 50402-56:
(7*5)+(6*0)+(5*4)+(4*0)+(3*2)+(2*5)+(1*6)=77
77 % 10 = 7
So 50402-56-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H14N2O3S/c13-7-8-14-11-5-1-4-10-9(11)3-2-6-12(10)18(15,16)17/h1-6,14H,7-8,13H2,(H,15,16,17)
50402-56-7Relevant articles and documents
Redox-based selective fluorometric detection of homocysteine
Peng, Hanjing,Wang, Ke,Dai, Chaofeng,Williamson, Samuel,Wang, Binghe
, p. 13668 - 13671 (2014)
Plasma homocysteine (Hcy) is an important risk factor for various diseases. A novel redox-sensitive fluorescent probe is developed for the selective detection of Hcy. A linear calibration curve has been obtained in buffer and plasma for the quantitative determination of Hcy in such media. This journal is
Fluorogenic Bifunctional trans-Cyclooctenes as Efficient Tools for Investigating Click-to-Release Kinetics
de Geus, Mark A. R.,Maurits, Elmer,Sarris, Alexi J. C.,Hansen, Thomas,Kloet, Max S.,Kamphorst, Kiki,ten Hoeve, Wolter,Robillard, Marc S.,Pannwitz, Andrea,Bonnet, Sylvestre A.,Codée, Jeroen D. C.,Filippov, Dmitri V.,Overkleeft, Herman S.,van Kasteren, Sander I.
supporting information, p. 9900 - 9904 (2020/06/05)
The inverse electron demand Diels–Alder pyridazine elimination reaction between tetrazines and allylic substituted trans-cyclooctenes (TCOs) is a key player in bioorthogonal bond cleavage reactions. Determining the rate of elimination of alkylamine substrates has so far proven difficult. Here, we report a fluorogenic tool consisting of a TCO-linked EDANS fluorophore and a DABCYL quencher for accurate determination of both the click and release rate constants for any tetrazine at physiologically relevant concentrations.
Multiconstituent liquid lgG and IgM calibrators
-
, (2008/06/13)
A serum in which are dissolved at least two heterologous antibodies, which are independently IgG or IgM and which specifically bind to different antigens, serves as a calibrator for multi-analyte immunoassays.
