50413-11-1

Basic information

• Product Name: 3(2H)-Thiophenone, 5-phenyl-
• CAS NO: 50413-11-1
• Molecular Formula: C10H8OS
• Molecular Weight: 176.239
• Mol File: 50413-11-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3(2H)-Thiophenone, 5-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Thiophenone, 5-phenyl-(50413-11-1)
• EPA Substance Registry System: 3(2H)-Thiophenone, 5-phenyl-(50413-11-1)

Safety Data

• Hazardous Substances Data: 50413-11-1(Hazardous Substances Data)

Upstream product

• 24127-62-6 methyl 2-bromo-3-phenylacrylate 
• 5556-23-0 3-Hydroxy-5-phenyl-thiophen-2-carbonsaeure-methylester 
• 103-26-4 methyl cinnamate 
• 112182-61-3 5-(1-methylsulfanyl-1-phenylmethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 
• 536-74-3 phenylacetylene 

Downstream Products

• 77643-81-3 (diphenyl-4,6 thiopyrannylidene-2)-2 phenyl-5 thiophenone-3 
• 859493-81-5 5-phenyl-thiophene-2,3-dione-2-oxime 
• 99689-90-4 5,5'-diphenyl-tetrahydro-[2,2']bithienylidene-3,3'-dione 

Relevant articles and documents

A new synthetic approach to thiophenes

A new simple and efficient way to 3-hydroxy(methoxy)thiophenes is described. The reactions of (ethylsulfanyl)acetyl fluoride/boron trifluoride (1) and 2-(ethylsulfanyl)butanoyl fluoride/boron trifluoride (6) complexes with acetylenes give rise to the 5-membered cyclic sulfonium salts (3a-f). The last ones (3e, 3f) after being refluxed with thiourea in methanol or acetonitrile are converted into 3-methoxythiophenes or 3-(2H)-thiophenones respectively. Several 3-methoxythiophenes unsubstituted in the 2-position were obtained by the reactions of 1 with acetylenes. Reactions of 6 with acetylenes allows the synthesis of 2-ethylsubsituted 3-methoxythiophenes. The method allows the synthesis of a variety of mono-, di-, tri- and tetrasubsituted thiophenes.

Synthesis of cyclic thioethers through tandem C(sp3)-S and C(sp2)-S bond formations from α,β′-dichloro vinyl ketones

(Chemical Equation Presented) The synthesis of 5- to 8-memebered cyclic thioethers 4 has been achieved through a simple two-step sequence. The present methodology utilizes the facile Friedel-Crafts acylation of terminal alkynes 1 with acid chlorides 2 fol