50415-70-8

Basic information

• Product Name: methyl 2-(p-chlorophenyl)propionate
• Synonyms: methyl 2-(p-chlorophenyl)propionate
• CAS NO: 50415-70-8
• Molecular Weight: 198.649
• Mol File: 50415-70-8.mol
• Article Data: 30

Chemical Properties

• CAS DataBase Reference: methyl 2-(p-chlorophenyl)propionate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-(p-chlorophenyl)propionate(50415-70-8)
• EPA Substance Registry System: methyl 2-(p-chlorophenyl)propionate(50415-70-8)

Safety Data

• Hazardous Substances Data: 50415-70-8(Hazardous Substances Data)

Upstream product

• 83022-49-5 2-Hydroxy-1,1-dimethoxy-1-(4-chlor-phenyl)-propan 
• 6285-05-8 4'-chloropropiophenone 
• 149-73-5 trimethyl orthoformate 
• 67-56-1 methanol 
• 105879-62-7 2(R)-(-)-4-chlorophenylpropanoic acid 
• 74-88-4 methyl iodide 
• 51747-43-4 2-(4-chlorophenyl)-acrylic acid 
• 106-39-8 bromochlorobenzene 
• 1073-67-2 4-vinylbenzyl chloride 
• 201230-82-2 carbon monoxide 
• 20001-59-6 1-(4-chlorophenyl)-ethyl methyl ether 
• 52449-43-1 (4-chloro-phenyl)-acetic acid methyl ester 
• 1878-66-6 4-chlorophenylacetic Acid 
• 3391-10-4 1-(p-chlorophenyl)ethyl alcohol 

Downstream Products

• 125670-62-4 α-methyl-4-cyanobenzeneacetic acid methyl ester 
• 286964-62-3 2-(4-chlorophenyl)propanal 
• 59667-21-9 p-Chloro-β-methylphenethyl alcohol 
• 872986-80-6 4-tert-butyl 1-methyl 2-(4-chlorophenyl)-2-methylsuccinate 
• 1034912-40-7 methyl 2-bromo-2-(4-chlorophenyl)propanoate 
• 938-95-4 2-(4-Chloro-phenyl)-propionic acid 

Relevant articles and documents

Palladium-Catalyzed Asymmetric Markovnikov Hydroxycarbonylation and Hydroalkoxycarbonylation of Vinyl Arenes: Synthesis of 2-Arylpropanoic Acids

Asymmetric hydroxycarbonylation is one of the most fundamental yet challenging methods for the synthesis of carboxylic acids. Herein, we reported the development of a palladium-catalyzed highly enantioselective Markovnikov hydroxycarbonylation of vinyl arenes with CO and water. A monodentate phosphoramidite ligand L6 plays vital role in the reaction. The reaction tolerates a range of functional groups, and provides a facile and atom-economical approach to an array of 2-arylpropanoic acids including several commonly used non-steroidal anti-inflammatory drugs. The catalytic system has also enabled an asymmetric Markovnikov hydroalkoxycarbonylation of vinyl arenes with alcohols to afford 2-arylpropanates. Mechanistic investigations suggested that the hydropalladation is irreversible and is the regio- and enantiodetermining step, while hydrolysis/alcoholysis is probably the rate-limiting step.

A general platinum-catalyzed alkoxycarbonylation of olefins

Hydroxy- and alkoxycarbonylation reactions constitute important industrial processes in homogeneous catalysis. Nowadays, palladium complexes constitute state-of-the-art catalysts for these transformations. Herein, we report the first efficient platinum-catalysed alkoxycarbonylations of olefins including sterically hindered and functionalized ones. This atom-efficient catalytic transformation provides straightforward access to a variety of valuable esters in good to excellent yields and often with high selectivities. In kinetic experiments the activities of Pd- and Pt-based catalysts were compared. Even at low catalyst loading, Pt shows high catalytic activity.

Iridium-Catalyzed α-Methylation of α-Aryl Esters Using Methanol as the C1 Source

IrCl(cod)2]/dppe-catalyzed α-methylation of aryl esters using methanol as the C1 source was developed. This methylation process is useful in several fields including organic chemistry, biochemistry, and medicinal chemistry. Readily available methanol as methylation reagent was successfully adapted. The reaction processed high atom economy and efficient. By applying the reaction system, the synthesis method of naproxen was provided.