50419-88-0Relevant articles and documents
QUINOLINO-PYRROLIDIN-2-ONE DERIVATIVE AND APPLICATION THEREOF
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Paragraph 0076-0077; 0083-0084, (2021/07/08)
Disclosed are a series of quinolino-pyrrolidin-2-one compounds, and application thereof in preparation of drugs for ATM inhibitor-related diseases. The present disclosure specifically relates to a derivative compound represented by formula (I), tautomers thereof or pharmaceutically acceptable compositions thereof.
A 5 - bromo - 4 - chloro - 2 - amino preparation method of acetophenone (by machine translation)
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Paragraph 0019; 0020; 0028; 0029; 0036; 0037, (2017/08/29)
The invention discloses a 5 - bromo - 4 - chloro - 2 - amino acetophenone preparation method, the method comprises the following steps: to 4 - chloro - 2 - aminobenzoic acid as the starting material, the reaction of halide 5 - bromo - 4 - chloro - 2 - ami
Indoxylic acid esters as convenient intermediates towards indoxyl glycosides
Boettcher, Stephan,Thiem, Joachim
, p. 564 - 574 (2014/02/14)
Indoxylic acid methyl and allyl esters with varied halide-substitution patterns were obtained in excellent yields using a scalable route. Phase-transfer glycosylation of these key intermediates was carried out with various glycosyl halides. Subsequent mild silver-mediated decarboxylation followed by Zemplen deacetylation led to indoxyl glycosides in good overall yields. Indoxyl glycosides are well-established and widely used tools for enzyme screening and enzyme-activity monitoring. In the past, their synthesis has been difficult, so this new approach has led to a variety of useful structures. Indoxyl glycosides with varied halide-substitution patterns were synthesized using indoxylic acid esters as key intermediates. Glycosylation under phase-transfer conditions, ester cleavage, and mild decarboxylation led to the indoxyl glycosides in good yields. This approach enables access to a number of different indoxyl compounds. Copyright