5042-03-5

Basic information

• Product Name: MESUAXANTHONE-B
• Synonyms: 1,5,6-Trihydroxy-9H-xanthene-9-one;C10082
• CAS NO: 5042-03-5
• Molecular Formula: C₁₃H₈O₅
• Molecular Weight: 244.2
• Product Categories: Xanthones
• Mol File: 5042-03-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 479.3°Cat760mmHg
• Flash Point: 192.2°C
• Appearance: /
• Density: 1.64g/cm³
• Vapor Pressure: 8.25E-10mmHg at 25°C
• Refractive Index: 1.758
• CAS DataBase Reference: MESUAXANTHONE-B(CAS DataBase Reference)
• NIST Chemistry Reference: MESUAXANTHONE-B(5042-03-5)
• EPA Substance Registry System: MESUAXANTHONE-B(5042-03-5)

Safety Data

• Hazardous Substances Data: 5042-03-5(Hazardous Substances Data)

Usage

Description

MESUAXANTHONE-B is a member of the class of xanthones that is 9H-xanthen-9-one substituted by hydroxy groups at positions 1, 5, and 6.

Uses

Used in Pharmaceutical Industry:
MESUAXANTHONE-B is used as a pharmaceutical compound for its potential therapeutic properties. Its unique structure with hydroxy groups at specific positions may contribute to its bioactivity and interactions with biological targets, making it a candidate for further research and development in the pharmaceutical field.
Used in Cosmetic Industry:
MESUAXANTHONE-B is used as an active ingredient in cosmetic products for its potential skin benefits. The presence of hydroxy groups may provide antioxidant and anti-inflammatory properties, which can be beneficial for skin health and protection against environmental stressors.
Used in Food Industry:
MESUAXANTHONE-B is used as a natural food additive for its potential health-promoting properties. Its antioxidant and anti-inflammatory activities may contribute to the enhancement of food products' nutritional value and overall health benefits.

InChI:InChI=1/C13H8O5/c14-7-2-1-3-9-10(7)11(16)6-4-5-8(15)12(17)13(6)18-9/h1-5,14-15,17H

Upstream product

• 303-07-1 2,6-Dihydroxybenzoic acid 
• 87-66-1 2-hydroxyresorcinol 
• 2150-45-0 methyl 2,6-dihydroxybenzoate 
• 1466-76-8 2-6-dimethoxybenzoic acid 
• 13739-15-6 1,5,6-trimethoxy-9H-xanthen-9-one 
• 1989-53-3 2,6-dimethoxybenzoyl chloride 
• 634-36-6 1,2,3-trimethoxybenzene 

Downstream Products

• 113681-58-6 5,6-dibenzyloxy-1-hydroxyxanthone 
• 113681-59-7 5,6-dibenzyloxy-1-methoxyxanthone 
• 1301159-81-8 7-hydroxy-2,2-diphenyl-6H-[1,3]dioxolo[4,5-c]xanthen-6-one 
• 1301159-87-4 7-(methoxymethoxy)-2,2-diphenyl-6H-[1,3]dioxolo[4,5-c]xanthen-6-one 
• 1338230-32-2 C₂₉H₂₂O₆ 

Relevant articles and documents

Combined Omics Approach Identifies Gambogic Acid and Related Xanthones as Covalent Inhibitors of the Serine Palmitoyltransferase Complex

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GARCINIA DERIVATIVE, ITS PREPARING METHOD AND MEDICINAL USE

The present invention relates to a field of pharmaceutical chemistry, more specifically, the present invention relates to a garcinia derivative Formula (I), its preparing method, and medicinal use. Wherein the definitions of R1 and R2 are disclosed in the specification of the present invention, and the derivative of the present invention is a structurally simplified analogue of the gambogic acid compound; wherein the gambogic acid compound possesses anti-cancer characteristics, and could be used for preparation of anti-tumor drugs.

Studies on chemical modification and biology of a natural product, gambogic acid (III): Determination of the essential pharmacophore for biological activity

Caged 4-oxa-tricyclo[4.3.1.03,7]dec-2-one structural motifs are found in Garcinia natural products that demonstrate anti-tumor activity. Gambogic acid (GA, 1), the most abundant caged Garcinia xanthones, has been reported to be a promising anti-cancer agent. To identify the essential pharmacophore for its anti-tumor activity, a series of GA analogues that address potential key structural features for biological activity were synthesized, among which compound 11a displayed comparable in vitro anti-tumor activity as GA. Mechanistic studies on 11a determined that the compound induces apoptosis as well as arrests the G2/M phase of the cell cycle in HepG2 cells. The determination of the essential part of the scaffold found in GA to maintain anti-tumor effects, and the SAR based on the caged pharmacophore are reported and will provide key information for future anti-cancer drug development studies.