50432-67-2

Basic information

• Product Name: 2-CHLORO-N4-METHYLPYRIDINE-3,4-DIAMINE
• Synonyms: 2-CHLORO-N4-METHYLPYRIDINE-3,4-DIAMINE
• CAS NO: 50432-67-2
• Molecular Formula: C₆H₈ClN₃
• Molecular Weight: 157.60082
• Product Categories: pharmacetical;Heterocycle-Pyridine series
• Mol File: 50432-67-2.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 2-CHLORO-N4-METHYLPYRIDINE-3,4-DIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-N4-METHYLPYRIDINE-3,4-DIAMINE(50432-67-2)
• EPA Substance Registry System: 2-CHLORO-N4-METHYLPYRIDINE-3,4-DIAMINE(50432-67-2)

Safety Data

• Hazardous Substances Data: 50432-67-2(Hazardous Substances Data)

Usage

General Description

2-Chloro-N4-methylpyridine-3,4-diamine is a chemical compound with the molecular formula C6H8ClN5. It is a type of pyridine derivative that contains a chlorine atom and a methyl group. 2-Chloro-N4-methylpyridine-3,4-diamine is commonly used in the pharmaceutical industry as a building block in the synthesis of various drugs and pharmaceutical products. It has also been studied for its potential biological and pharmacological properties. Additionally, 2-Chloro-N4-methylpyridine-3,4-diamine is a known mutagen and has been identified as a potential environmental hazard, so proper safety precautions should be taken when handling this substance.

Upstream product

• 1633-41-6 3-nitro-4-methylaminopyridine 
• 50432-68-3 4-chloro-1-methyl-1H-imidazo(4,5-c)pyridine 
• 1239719-69-7 2 -chloro-N-methyl-3-nitropyridin-4-amine 
• 5975-12-2 2,4-dichloro-3-nitro-pyridine 

Downstream Products

• 50432-68-3 4-chloro-1-methyl-1H-imidazo(4,5-c)pyridine 
• 496955-69-2 benzyl-(1-methyl-2-([1,2,3]triazol-2-yl)-1H-imidazo[4,5-c]pyridin-4-yl)amine 
• 61719-59-3 4-Chlor-1-methylimidazo-<4,5-c>-2-pyridon 
• 1240610-76-7 C₁₄H₁₃Cl₂N₃O₂ 
• 1248539-97-0 4-chloro-1-methyl-7-nitro-1H-[1,2,3]triazolo[4,5-c]pyridine 2-oxide 

Relevant articles and documents

Identification of 2,4-Disubstituted Imidazopyridines as Hemozoin Formation Inhibitors with Fast-Killing Kinetics and in Vivo Efficacy in the Plasmodium falciparum NSG Mouse Model

A series of 2,4-disubstituted imidazopyridines, originating from a SoftFocus Kinase library, was identified from a high throughput phenotypic screen against the human malaria parasite Plasmodium falciparum. Hit compounds showed moderate asexual blood stage activity. During lead optimization, several issues were flagged such as cross-resistance against the multidrug-resistant K1 strain, in vitro cytotoxicity, and cardiotoxicity and were addressed through structure-Activity and structure-property relationship studies. Pharmacokinetic properties were assessed in mice for compounds showing desirable in vitro activity, a selectivity window over cytotoxicity, and microsomal metabolic stability. Frontrunner compound 37 showed good exposure in mice combined with good in vitro activity against the malaria parasite, which translated into in vivo efficacy in the P. falciparum NOD-scid IL-2Rnull (NSG) mouse model. Preliminary mechanistic studies suggest inhibition of hemozoin formation as a contributing mode of action.

PHARMACOLOGICALLY ACTIVE IMIDAZO[4,5-C]PYRIDINES

The invention relates to 6-substituted imidazo[4,5-c]pyridines of formula 1, in which X is O (oxygen) or NH and Y has either the meaning -CH2-AR or Y denotes the group gp (gp) wherein Z has the meaning -CHR8- or -CHR8-CHR9-. The compounds have gastric secretion inhibiting and excellent gastric and intestinal protective action properties.

1,3-DIHYDROIMIDAZOLE FUSED-RING COMPOUND

The objective of this invention is to provide novel compounds that show excellent DPPIV-inhibiting activity. The present invention provides compounds represented by the general formula (I), salts thereof, or hydrates thereof, [wherein,T1 stands for a monocyclic or bicyclic 4 to 12-membered heterocycle having 1 or 2 nitrogen atoms in the ring, which may have substituents; in formula (I), the following formula represents a double bond or a single bond; X3 denotes an oxygen atom or a sulfur atom; X1 denotes a C2-6 alkynyl group which may have substituents; Z1 denotes a nitrogen atom or the formula -CR3=; Z2 and Z3 each independently denote a nitrogen atom, the formula -CR1=, a carbonyl group, or the formula -NR2-; R1, R2, R3, and X2 each independently denote a C1-6 alkyl group which may have substituents, and such].