50483-74-4

Basic information

• Product Name: 3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole
• Synonyms: 3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole
• CAS NO: 50483-74-4
• Molecular Weight: 252.34
• Mol File: 50483-74-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole(50483-74-4)
• EPA Substance Registry System: 3-phenyl-5-(p-tolyl)-1,2,4-thiadiazole(50483-74-4)

Safety Data

• Hazardous Substances Data: 50483-74-4(Hazardous Substances Data)

Upstream product

• 1670-14-0 benzamidine monohydrochloride 
• 104-81-4 4-Methylbenzyl bromide 
• 622-47-9 4-tolylacetic acid 
• 104-82-5 4-Methylbenzyl chloride 
• 104-85-8 para-methylbenzonitrile 
• 5852-49-3 5-phenyl-1,3,4-oxathiazol-2-one 

Relevant articles and documents

A copper-catalyzed approach for the synthesis of asymmetrical disubstituted 1,2,4-thiadiazoles via elemental sulfur-mediated decarboxylative redox cyclization

The variety of asymmetrical disubstituted 1,2,4-thiadiazoles are smoothly prepared by copper-catalyzed approach, which employed arylacetic acids and amidines as substrates, and elemental sulfur to mediate decarboxylative redox cyclization. The advantages of this method are simple, efficient, and ligand-free. In addition, this method can provide products in moderate to good yields.

An alternatively metal-free synthesis of 1,3,5-triazines or 1,2,4-thiadiazoles from benzyl chlorides and benzylamines mediated by elemental sulfur

An elemental sulfur mediated reaction of benzyl chlorides with benzylamines is developed, which allows the practical synthesis of valuable 1,3,5-triazines. This protocol that is metal free, ligand free, and uses inexpensive elemental sulfur as oxidant or raw material displays mild reaction conditions, a broad substrate scope and moderate to good yields. Moreover, the modified sulfur-mediated reaction system can also be used to synthesize 1,2,4-thiadiazoles, by simply switching the stoichiometry of sulfur powder from 0.75 equivalents to 5 equivalents.