50487-77-9

Basic information

• Product Name: N-(2,3-dibromopropyl)benzamide
• Synonyms: N-(2,3-dibromopropyl)benzamide
• CAS NO: 50487-77-9
• Molecular Weight: 321.011
• Mol File: 50487-77-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(2,3-dibromopropyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,3-dibromopropyl)benzamide(50487-77-9)
• EPA Substance Registry System: N-(2,3-dibromopropyl)benzamide(50487-77-9)

Safety Data

• Hazardous Substances Data: 50487-77-9(Hazardous Substances Data)

Upstream product

• 10283-95-1 N-allylbenzamide 
• 65-85-0 benzoic acid 
• 98-88-4 benzoyl chloride 
• 6963-32-2 2,3-dibromopropylamine hydrobromide 

Downstream Products

• 99057-83-7 5-bromomethyl-2-phenyl-Δ²-1,3-oxazoline 
• 80281-50-1 5-(bromomethyl)-2-phenyloxazole 

Relevant articles and documents

CuBr2-promoted intramolecular bromocyclization of N-allylamides and aryl allyl ketone oximes

A new and easy-to-perform route to 2-oxazolines amd isoxazolines was reported. Using CuBr2 as both the bromide source and the reaction promoter, bromocyclization of N-allylamides and allyl ketone oximes proceeded readily, leading to oxazolines

Synthesis of Δ2-1,3-oxazolines and Δ2-1,3-oxazines using potassium fluoride on alumina

Potassium fluoride (40%) on alumina was used as a basic reagent for the ring closure of N-(β- or γ-haloalkyl)amides to give Δ2-1,3-oxazolines and Δ2-1,3-oxazines, respectively. Various 2-alkyl and 2-aryl derivatives were synthesized in moderate to high yield under relatively mild conditions (KF/Al2O3, solvent, room temperature). The procedure also facilitated simple workup and purification of the products. New compounds synthesized by this method are: 5-bromomethyl-2-phenyl-Δ2-1,3-oxazoline, 4,4-dimethyl-2-vinyl-Δ2-1,3-oxazoline, and 5-methylene-2-phenyl-Δ2-1,3-oxazine. The last compound represents the first authentic example of a 5-functionally substituted oxazine without substitution in the 4- or the 6-position.