50501-38-7Relevant articles and documents
Synthesis and spectroscopy of anionic tridentate benzimidazole-pyridine carboxylate and tetrazolate chromophore ligands
Shavaleev, Nail M.,Eliseeva, Svetlana V.
, p. 81 - 86 (2015)
We report on seven new anionic benzimidazole-pyridine carboxylate and tetrazolate tridentate N^N^O and N^N^N ligands that are modified with chromophore (phenyl, biphenyl, naphthyl) and solubilizing groups. The ligands are UV chromophores with the lowest-energy absorption maxima at 312-335 nm and with the molar absorption coefficients of (20-25) × 103 M-1 cm-1 in DMSO solution. The ligands form neutral complexes with trivalent lanthanides and sensitize the red luminescence of europium. The triplet state energies of the deprotonated ligands, which were measured from the phosphorescence spectra of their lanthanum complexes at 77 K, are in the range of (18.8-21.1) × 103 cm-1. We also describe synthesis of non-symmetric pyridines that are 2,6- and 2,4,6-substituted with hydroxymethyl, carboxaldehyde, and carbonitrile groups.
Synthesis and structure-activity relationships of amide derivatives of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetic acid as selective arginine vasopressin V2 receptor agonists
Tsukamoto, Issei,Koshio, Hiroyuki,Kuramochi, Takahiro,Saitoh, Chikashi,Yanai-Inamura, Hiroko,Kitada-Nozawa, Chika,Yamamoto, Eisaku,Yatsu, Takeyuki,Shimada, Yoshiaki,Sakamoto, Shuichi,Tsukamoto, Shin-ichi
experimental part, p. 3130 - 3141 (2009/09/30)
A series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives was synthesized, and their structure-activity relationships were examined in order to identify potent and selective arginine vasopressin V2 receptor agonists. Attempts to substitute other chemical groups in place of the 2-pyridilmethyl moiety of 1a led to the discovery that potent V2 binding affinity could be obtained with a wide range of functional groups. This structural tolerance allowed for the manipulation of other attributes, such as selectivity against V1a receptor affinity or avoidance of the undesirable inhibition of cytochrome P450 (CYP), without losing potent affinity for the V2 receptor. Some representative compounds obtained in this study were also found to decrease urine volume in awake rats.
4-HETEROARYLMETHYL SUBSTITUTED PHTHALAZINONE DERIVATIVES
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Page/Page column 44-45, (2008/06/13)
A compound of formula (I): for use in treating cancer or other diseases ameliorated by the inhibition of PARP, wherein: A and B together represent an optionally substituted, fused aromatic ring; X can be NRx or CRxRy; if X=NRx then n is 1 or 2 and if X=CRxRy then n is 1; Rx is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; Ry is selected from H, hydroxy, amino; or Rx and Ry may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are independently selected from the group consisting of hydrogen and C1-4 alkyl, or when X is CRxRy, RC1, RC2, Rx and Ry, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; R1 is selected from H and halo; and Het is selected from: (i) formula (i), where Y1 is selected from CH and N, Y2 is selected from CH and N, Y3 is selected from CH, CF and N, where only one or two of Y1, Y2 and Y3 can be N; and (ii) formula (ii), where Q is O or S.
