505052-84-6

Basic information

• Product Name: 2-(4-methylphenyl)-4H-3,1-benzothiazine
• Synonyms: 2-(4-methylphenyl)-4H-3,1-benzothiazine
• CAS NO: 505052-84-6
• Molecular Weight: 239.341
• Mol File: 505052-84-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-(4-methylphenyl)-4H-3,1-benzothiazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methylphenyl)-4H-3,1-benzothiazine(505052-84-6)
• EPA Substance Registry System: 2-(4-methylphenyl)-4H-3,1-benzothiazine(505052-84-6)

Safety Data

• Hazardous Substances Data: 505052-84-6(Hazardous Substances Data)

Upstream product

• 2362-62-1 4-methylthiobenzamide 
• 5344-90-1 2-Aminobenzyl alcohol 
• 505052-76-6 4-methyl-benzoic acid 2-(4-methyl-thiobenzoylamino)-benzyl ester 
• 114059-99-3 ortho-(chloromethyl)-aniline 
• 88301-81-9 o-aminobenzyl chloride hydrochloride 

Downstream Products

• 1005311-28-3 2,2-dichloro-2a-(4-methylphenyl)-2,2a-dihydro-2H,4H-azeto[1,2-a][3,1]benzothiazin-1-one 

Relevant articles and documents

A metal-A nd base-free domino protocol for the synthesis of 1,3-benzoselenazines, 1,3-benzothiazines and related scaffolds

Efficient protocols have been described for the synthesis of 1,3-benzoselenazines, 1,3-benzothiazines, 2-aryl thiazin-4-ones and diaryl[b,f][1,5]diazocine-6,12(5H,11H)-diones. These transformations were successfully driven towards the product formation under mild acid catalyzed reaction conditions at room temperature using 2-amino aryl/hetero-aryl alkyl alcohols and amides as substrates. The merits of the present methods also rely on the easy access of rarely explored bioactive scaffolds like 1,3-benzoselenazine derivatives, for which well-documented methods are rarely known in the literature. A broad range of substrates with both electron-rich and electron-deficient groups were well-tolerated under the developed conditions to furnish the desired products in yields up to 98%. The scope of the devised method is not only restricted to the synthesis of 1,3-benzoselenazines, but it was also further extended towards the synthesis of 1,3-benzothiazines, 1,3-benzothiazinones and the corresponding eight membered N-heterocycles such as diaryl[b,f][1,5]diazocine-6,12(5H,11H)-diones.

Novel β-lactam condensed 3-thiaquinolines: an efficient synthesis and structural characterization

Quinoline analog 2-aryl-4H-3,1-benzothiazine derivatives 8-13, obtained by the condensation of o-aminobenzyl chloride 1 with?substituted thiobenzamides 2-7, were transformed to azeto[2,1-a][3,1]benzothiazin-1-one derivatives 18-23a,b,c and 24d,e by reaction with the corresponding substituted acetyl chlorides 14-17 in the presence of triethylamine. The structures of the new molecules were determined by NMR spectroscopy and electron ionization (EI) mass spectrometry. The typical EI+ mass spectrometric fragmentations of 8-13 and 18-23a,b,c and 24d,e are discussed in detail.