50508-66-2

Basic information

• Product Name: 2-AMino-3-(p-chlorobenzoyl)-4,5-diMethylthiophene
• Synonyms: 2-AMino-3-(p-chlorobenzoyl)-4,5-diMethylthiophene;(2-aMino-4,5-diMethylthiophen-3-yl)(4-chlorophenyl)Methanone;Methanone, (2-aMino-4,5-diMethyl-3-thienyl)(4-chlorophenyl)-;Mino-3-(p-chlorobenzoyl)-4,5-diMethylthiophene;2-AMino-3-(p-chlorobenzoyl)-4,5-diMethylthiophene 2-AMino-3-(p-chlorobenzoyl)-4,5-diMethylthiophene
• CAS NO: 50508-66-2
• Molecular Formula: C₁₃H₁₂ClNOS
• Molecular Weight: 265.75848
• Mol File: 50508-66-2.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 435.4±45.0 °C(Predicted)
• Appearance: /
• Density: 1.303±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: -1.34±0.13(Predicted)
• CAS DataBase Reference: 2-AMino-3-(p-chlorobenzoyl)-4,5-diMethylthiophene(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-3-(p-chlorobenzoyl)-4,5-diMethylthiophene(50508-66-2)
• EPA Substance Registry System: 2-AMino-3-(p-chlorobenzoyl)-4,5-diMethylthiophene(50508-66-2)

Safety Data

• Hazardous Substances Data: 50508-66-2(Hazardous Substances Data)

Usage

General Description

2-Amino-3-(p-chlorobenzoyl)-4,5-dimethylthiophene is a chemical compound that contains a thiophene ring with substituents at the 2 and 3 positions. The compound also contains an amino group at the 2 position and a p-chlorobenzoyl group at the 3 position. Additionally, there are two methyl groups attached to the 4 and 5 positions of the thiophene ring. 2-AMino-3-(p-chlorobenzoyl)-4,5-diMethylthiophene has potential applications in organic synthesis and pharmaceutical research due to its structural features and potential pharmacological properties.

Upstream product

• 78-93-3 butanone 
• 4640-66-8 p-chlorobenzoylacetonitrile 
• 937-20-2 p-chlorophenacyl chloride 
• 873-76-7 para-Chlorobenzyl alcohol 
• 1126-46-1 Methyl 4-chlorobenzoate 

Downstream Products

• 1027493-33-9 2-[3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2-yl]isoindoline-1,3-dione 
• 1268524-66-8 (S)-tert-butyl-3-amino-4-((3-(4-chlorobenzoyl)-4,5-dimethylthiophen-2-yl)amino)-4-oxobutanoate 
• 1268524-67-9 tert-butyl (S)-2-(5-(4-chlorophenyl)-6,7-dimethyl-2-oxo-2,3-dihydro-1H-thieno[2,3-e][1,4]diazepin-3-yl)acetate 
• 1268524-70-4 (S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate 
• 1027493-20-4 {2-Amino-5-methyl-4-[(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl]thiophen-3-yl}(4-chlorophenyl)methanone 
• 1027493-22-6 {2-Amino-4-[(4-(4-chloro-3-(trifluoromethyl)phenyl)piperazin-1-yl)methyl]-5-methylthiophen-3-yl}(4-chlorophenyl)methanone 
• 1027493-34-0 2-[4-bromomethyl-3-(4-chlorobenzoyl)-5-methylthiophen-2-yl]isoindoline-1,3-dione 
• 1394867-70-9 2-[3-(4-chlorobenzoyl)-5-methyl-4-[(4-phenylpiperazin-1-yl)methyl]thiophen-2-yl]isoindoline-1,3-dione 
• 1394867-71-0 2-[4-[(4-benzylpiperazin-1-yl)methyl]-3-(4-chlorobenzoyl)-5-methylthiophen-2-yl]isoindoline-1,3-dione 
• 1027493-35-1 2-{3-(4-chlorobenzoyl)-4-[(4-(4-fluorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione 
• 1394867-72-1 2-{3-(4-chlorobenzoyl)-4-[(4-(4-chlorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione 
• 1394867-73-2 2-{3-(4-chlorobenzoyl)-4-[(4-(3-chlorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione 
• 1394867-74-3 2-{3-(4-chlorobenzoyl)-4-[(4-(3,4-dichlorophenyl)piperazin-1-yl)methyl]-5-methylthiophen-2-yl}isoindoline-1,3-dione 
• 1394867-75-4 2-{4-[(4-(4-bromophenyl)piperazin-1-yl)methyl]-3-(4-chlorobenzoyl)-5-methylthiophen-2-yl}isoindoline-1,3-dione 

Relevant articles and documents

COMPOUNDS HAVING BOTH EFFECTS OF BET BROMODOMAIN PROTEIN INHIBITION AND PD-L1 GENE REGULATION

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Potent Dual BET/HDAC Inhibitors for Efficient Treatment of Pancreatic Cancer

As one of the most aggressive and lethal human malignancies with extremely poor prognosis, there is an urgent demand of more effective therapy for the treatment of pancreatic cancer. Reported here is a new, effective therapeutic strategy and the design of small-molecule inhibitors that simultaneously target bromodomain and extra-terminal (BET) and histone deacetylase (HDAC), potentially serving as promising therapeutic agents for pancreatic cancer. A highly potent dual inhibitor (13 a) is identified to possess excellent and balanced activities against BRD4 BD1 (IC50=11 nm) and HDAC1 (IC50=21 nm). Notably, this compound shows higher in vitro and in vivo antitumor potency than the BET inhibitor (+)-JQ1 and the HDAC inhibitor vorinostat, either alone or and in combination, highlighting the advantages of BET/HDAC dual inhibitors for more effective treatment of pancreatic cancer.

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The invention relates to compounds of the formula: and pharmaceutically acceptable salts thereof. These compounds are useful in the treatment of inflammatory diseases, fibtrotic diseases and neoplastic diseases.