5053-08-7 Usage
Description
Fenspiride hydrochloride is a bronchodilator with anti-inflammatory properties. It inhibits mucus secretion and reduces the release of tachykinins at a prejunctional level by its anti-muscarinic action. Additionally, it may act as an antagonist at α adrenergic and H1 histamine receptors.
Uses
Used in Pharmaceutical Industry:
Fenspiride hydrochloride is used as an anti-inflammatory agent for its ability to reduce inflammation in the respiratory system.
Fenspiride hydrochloride is used as a bronchodilator for its ability to relax and widen the airways, improving airflow and reducing symptoms of respiratory conditions.
Fenspiride hydrochloride is used as a Bradykinin antagonist for its ability to block the effects of Bradykinin, a peptide that can cause inflammation and bronchoconstriction.
Fenspiride hydrochloride is used as an antagonist at α adrenergic and H1 histamine receptors for its ability to block these receptors, reducing the effects of histamine and norepinephrine, which can contribute to inflammation and bronchoconstriction.
Pharmacological effects
As an α adrenergic and H1 histamine receptor antagonist, Fenspiride has been shown to be antiinflammatory, anti-allergic and antioxidant. Fenspiride inhibited SO2-induced goblet cell hyperplasia in rats, with concomitant inhibition of increased hexose and fucose, indicative of mucus hypersecretion, in lavage fluid. Fenspiride also exhibits neuronal inhibitory activity. For example, in guinea pigs, it reverses capsaicin-induced and citric acid-induced bronchoconstriction and cough, and inhibits cholinergic and non-adrenergic, non-cholinergic (NANC) neural contraction of isolated bronchi.
Indications
Fenspiride hydrochloride is a bronchodilator, which was used as a drug in the treatment of certain respiratory diseases. Finsecbili hydrochloride against serotonin, dilating bronchial smooth muscle, the intensity of action is between isoproterenol and theophylline, in addition to reducing the resistance of air movement in the lungs, experiments have shown that this product has dilated bronchial smooth muscle, antitussive, antipyretic and analgesic effects. Suitable for chronic bronchitis, bronchial asthma and chronic respiratory insufficiency.? In Russia it was approved for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract, as well as for maintenance treatment of asthma (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis).
Therapeutic Function
Bronchodilator
Check Digit Verification of cas no
The CAS Registry Mumber 5053-08-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,0,5 and 3 respectively; the second part has 2 digits, 0 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 5053-08:
(6*5)+(5*0)+(4*5)+(3*3)+(2*0)+(1*8)=67
67 % 10 = 7
So 5053-08-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H20N2O2.ClH/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13;/h1-5H,6-12H2,(H,16,18);1H
5053-08-7Relevant articles and documents
Nitro-Aldol Approach for Commercial Manufacturing of Fenspiride Hydrochloride
Pramanik, Chinmoy,Bapat, Kiran,Patil, Pradip,Kotharkar, Sandeep,More, Yogesh,Gotrane, Dinkar,Chaskar, Sudhir P.,Mahajan, Ulhas,Tripathy, Narendra K.
, p. 1252 - 1256 (2019)
An efficient, short manufacturing process for fenspiride hydrochloride is reported. Nitro-aldol condensation is the key reaction in the developed process. Improved routes to key building blocks are demonstrated by expedient multikilogram production. Hazardous reactions are avoided. API produced following this new route meets the quality requirement NLT 99.70% purity by HPLC with any individual impurity NMT 0.10% with very good yield.
