5054-32-0

Basic information

• Product Name: 2-Amino-3-methylbenzophenone
• Synonyms: 2-Amino-3-methylbenzophenone
• CAS NO: 5054-32-0
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.26
• Mol File: 5054-32-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Amino-3-methylbenzophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-methylbenzophenone(5054-32-0)
• EPA Substance Registry System: 2-Amino-3-methylbenzophenone(5054-32-0)

Safety Data

• Hazardous Substances Data: 5054-32-0(Hazardous Substances Data)

Usage

General Description

2-Amino-3-methylbenzophenone, also known as 2-aminobenzophenone-3 or Oxybenzone-4, is a chemical compound with the molecular formula C14H13NO. It is a yellow crystalline solid that is commonly used as a sunscreen ingredient to absorb and reflect UV radiation. 2-Amino-3-methylbenzophenone is part of the benzophenone family and is added to sunscreens, lip balms, and other personal care products to protect the skin from sun damage. However, concerns have been raised about its potential to cause skin allergies and hormone disruption. It has been banned in some countries or restricted in its use due to these health and environmental concerns.

Upstream product

• 60288-18-8 N-(2-benzoyl-6-methylphenyl)acetamide 
• 584-70-3 N-benzoyl-2-methylaniline 
• 60288-17-7 2,8-dimethyl-4H-3,1-benzoxazin-4-one 
• 108-86-1 bromobenzene 
• 886574-89-6 2-amino-N-methoxy-N,3-dimethylbenzamide 
• 4389-45-1 3-methylantranilic acid 
• 100-47-0 benzonitrile 
• 95-53-4 o-toluidine 

Downstream Products

• 60287-75-4 2-Benzyl-6-methylanilin 
• 114623-44-8 7-methyl-3-phenyl-2,1-benzisoxazole 
• 80726-58-5 (2-chloro-3-methylphenyl)phenylmethanone 
• 80726-59-6 (3-Bromomethyl-2-chloro-phenyl)-phenyl-methanone 
• 80726-60-9 3-benzoyl-2-chlorobenzeneacetonitrile 
• 80726-61-0 3-benzoyl-2-chlorobenzeneacetic acid 
• 1584139-99-0 benzyl (9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)carbamate 
• 1584139-93-4 (S)-benzyl (9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e] [1,4]diazepin-3-yl)carbamate 
• 1584139-82-1 (S)-3-amino-9-methyl-5-phenyl-1H-benzo[e][1,4]diazepin-2(3H)-one 
• 1584139-23-0 (2R,3S)-3-((1-fluorocyclobutyl)methyl)-N-((3S)-9-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepin-3-yl)-2-(3,3,3-trifluoropropyl)succinamide 
• 52164-35-9 (2-iodo-3-methylphenyl)(phenyl)methanone 
• 4937-64-8 9-methyl-5-phenyl-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one 

Relevant articles and documents

Atropisomeric Properties of 9-Methyl-1,4-benzodiazepin-2-ones

The atropisomeric and conformational properties of 1,4-benzodiazepin-2-ones were investigated by freezing the conformation with a methyl group at the C9 of 1,4-benzodiazepine. It was revealed that 1,4-benzodiazepin-2-ones exist only as a pair of enantiome

Deoxygenative Arylation of Carboxylic Acids by Aryl Migration

An unprecedented deoxygenative arylation of aromatic carboxylic acids has been achieved, allowing the construction of an enhanced library of unsymmetrical diaryl ketones. The synergistic photoredox catalysis and phosphoranyl radical chemistry allows for precise cleavage of a stronger C?O bond and formation of a weaker C?C bond by 1,5-aryl migration under mild reaction conditions. This new protocol is independent of substrate redox-potential, electronic, and substituent effects. It affords a general and promising access to 60 examples of synthetically versatile o-amino and o-hydroxy diaryl ketones under redox-neutral conditions. Furthermore, it also brings one concise route to the total synthesis of quinolone alkaloid, (±)-yaequinolone A2, and a viridicatin derivative in satisfying yields.

Palladium-Catalyzed Cascade Reductive and Carbonylative Cyclization of Ortho-Iodo-Tethered Methylenecyclopropanes (MCPs) Using N-Formylsaccharin as CO Source

A palladium-catalyzed reductive and carbonylative cyclization of ortho-iodo-tethered methylenecyclopropanes (MCPs) using N-formylsaccharin as CO source has been developed, affording the desired indanone derivatives in moderate to good yields with high regio- and stereoselectivity and good functional group compatibility.