50585-73-4

Basic information

• Product Name: Methanesulfonamide, N-(3-benzoylphenyl)-
• CAS NO: 50585-73-4
• Molecular Formula: C14H13NO3S
• Molecular Weight: 275.328
• Mol File: 50585-73-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Methanesulfonamide, N-(3-benzoylphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Methanesulfonamide, N-(3-benzoylphenyl)-(50585-73-4)
• EPA Substance Registry System: Methanesulfonamide, N-(3-benzoylphenyl)-(50585-73-4)

Safety Data

• Hazardous Substances Data: 50585-73-4(Hazardous Substances Data)

Upstream product

• 2835-78-1 3-amino benzophenone 
• 124-63-0 methanesulfonyl chloride 

Relevant articles and documents

COX-1/COX-2 inhibitors based on the methanone moiety

This paper focuses on the synthesis and the in vitro testing of dual COX-1/COX-2 inhibitors. Starting from structures of non-steroidal anti-inflammatory drugs (NSAIDs) the diaryl methanone element was chosen as a lead. Modifications were carried out on this scaffold to obtain potent inhibitors of the COX enzymes. The N-(2-aroylphenyl)sulphonamides and -amides were studied in detail, and to consolidate the data evaluated the corresponding 3- and 4-regioisomers were also investigated. The potency and the enzyme selectivity were varied by structural modifications of the lead.