506-48-9Relevant articles and documents
Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer's agent
Zhang, Hong-Yan,Yamakawa, Yu-Ichiro,Matsuya, Yuji,Toyooka, Naoki,Tohda, Chihiro,Awale, Suresh,Li, Feng,Kadota, Shigetoshi,Tezuka, Yasuhiro
, p. 604 - 608 (2014/01/23)
In order to develop new drugs for Alzheimer's disease, we prepared 17 fatty acid derivatives with different chain lengths and different numbers and positions of double bonds by using Wittig reaction and stereospecific hydrogenation of triple bonds as key reactions. Among them, (4Z,15Z)- octadecadienoic acid (10) and (23Z,34Z)-heptatriacontadienoic acid (16) showed the most potent neurite outgrowth activities on Aβ(25-35)-treated rat cortical neurons, which activities were comparable to that of a positive control, NGF. Both fatty acids 10 and 16 possess two (Z)-double bonds at the n-3 and n-14 positions, which might be important for the neurite outgrowth activity.
HEPTATRIACONTAN-4-ONE, TETRATRIACONTANYL OCTACOSANOATE AND OTHER CONSTITUENTS FROM PEDALIUM MUREX
Shukla, Yogendra N.,Thakur, Raghunath
, p. 973 - 974 (2007/10/02)
Key Word Index - Pedalium murex; Pedaliaceae; fruits; heptatriacontan-4-one; tetratriacontanyl octacosanoate; pentatriacontane; hexatriacontanois acid; hentatriacontanoic acid; ursolic acid; vanillin. Two new compounds isolated from the fruits of Pedalium murex are characterized as heptatriacontan-4-oneand tetratriacontanyl octacosanoate by spectral studies.Pentatriacontane, sitosterol, hexatriacontanoic acid, hentriacontanoic acid, ursolic acid and vanillin have also been isolated and identified.