50654-43-8

Basic information

• Product Name: 1-(hydroxymethyl)cyclohexanecarbonitrile
• Synonyms: 1-(hydroxymethyl)cyclohexanecarbonitrile
• CAS NO: 50654-43-8
• Molecular Weight: 139.197
• Mol File: 50654-43-8.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 1-(hydroxymethyl)cyclohexanecarbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(hydroxymethyl)cyclohexanecarbonitrile(50654-43-8)
• EPA Substance Registry System: 1-(hydroxymethyl)cyclohexanecarbonitrile(50654-43-8)

Safety Data

• Hazardous Substances Data: 50654-43-8(Hazardous Substances Data)

Usage

Chemical structure

A cyclohexane ring with a hydroxymethyl group and a nitrile group attached to it.

Composition

Contains carbon, hydrogen, and oxygen atoms.

Functional groups

Hydroxymethyl (-CH2OH) and nitrile (-CN) groups.

Applications

Widely used in the synthesis of pharmaceuticals and agrochemicals.

Reactivity

Versatile reactivity due to the presence of multiple functional groups.

Derivatives

Can undergo various chemical reactions to produce different derivatives with unique properties and applications.

Industrial importance

Serves as a valuable building block in chemical synthesis with a wide range of potential industrial applications.

Safety concerns

Should be handled with care as it may pose health risks if not handled properly.

Physical state

Likely a liquid or solid at room temperature, depending on the specific conditions.

Solubility

Soluble in organic solvents, such as ethanol or acetone, due to its nonpolar cyclohexane ring and functional groups.

Upstream product

• 1130-21-8 ethyl 1-cyanocyclohexane-1-carboxylate 
• 628-77-3 1,5-diiodopentane 
• 83576-38-9 1-Cyano-cyclohexanecarbothioic acid S-tert-butyl ester 
• 50-00-0 formaldehyd 
• 766-05-2 cyclohexane carbonitrile 

Downstream Products

• 956518-70-0 1-formylcyclohexanecarbonitrile 
• 666-08-0 2-azaspiro<3.5>nonane 

Relevant articles and documents

Synthesis of Spirocyclic β- and γ-Sultams by One-Pot Reductive Cyclization of Cyanoalkylsulfonyl Fluorides

One-pot intramolecular cyclization of novel sp3-enriched cyanoalkylsulfonyl fluorides into spirocyclic β- or γ-sultams is disclosed. The method relies on nitrile group reduction followed by sulfonylation of amino group thus formed upon mild con

BENZISOXAZOLE COMPOUND

Disclosed is a compound represented by the general formula (I) or a salt thereof: wherein any one of R1, R2 and R3 represents a group represented by the formula: -(CH2)m-NR11R12 (wherein m is 1 or 2; and R11 and R12 independently represent a hydrogen atom or a C1-6 alkyl group or may, together with a nitrogen atom to which R11 and R12 are bound, form a 4- or 5-membered cyclic group); the remaining two or R1, R2 and R3 independently represent a group represented by the formula: -(O)n-R21 (wherein n is 0 or 1; and R21 represents a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C2-6 alkynyl group, or the like); and R4 represents a C1-6 alkyl group which may have a substituent or the like.

THIOL ESTERS IN ORGANIC SYNTHESIS. XI. A FACILE APPROACH TO β-HYDROXYPROPIONITRILES AND ACRYLONITRILES. CYANOTHIOLACETATE AS MASKED β-HYDROXYPROPIONITRILE CARBANION

The preparation of β-hydroxypropionitriles and acrylonitriles is facilitated by the use of cyanothiolacetate as a formal equivalent of β-hydroxypropionitrile carbanion.