5066-50-2Relevant articles and documents
Gambogic acid-galactose-HPMA (N-(2-hydroxypropyl)methacrylamide) high-molecular copolymer, and preparation method and application thereof
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Paragraph 0037; 0040, (2017/08/30)
The invention discloses a gambogic acid-galactose-HPMA (N-(2-hydroxypropyl)methacrylamide) high-molecular copolymer. The structural formula is shown as (I) in the specification. In the formula, x=5-10 mol%, y=5-10 mol%, z=80-90 mol%, Mn=2.2*10, and Mw/Mn=1.45. A preparation method comprises the following steps: preparing a galactose derivative C by taking D-galactose as a preparation raw material; reacting gambogic acid oxalamide and methylacryloyl to prepare a gambogic acid derivative D; and finally, performing condensation on the galactose derivative C, the gambogic acid derivative D and HPMA to obtain the gambogic acid-galactose-HPMA high-molecular copolymer. After being used in a drug for treating a neoplastic disease, the copolymer has a targeted intelligent drug release functional and achieves a favorable inhibition effect for liver cancer, lung cancer and colon cancer.
Intracellular protein delivery by glucose-coated polymeric beads
Jung, Suhyun,Huh, Seong,Cheon, Yong-Pil,Park, Seongsoon
supporting information; experimental part, p. 5003 - 5005 (2010/01/06)
Glucose-coated polymeric beads have been prepared and applied to delivery of a model protein (enhanced green fluorescent protein) into mouse embryonic stem cells as well as Hela cells.
Differential activities of a lipase and a protease toward straight- and branched-chain acyl donors in transesterification to carbohydrates in an organic medium
Watanabe, Takashi,Matsue, Rika,Honda, Yoichi,Kuwahara, Masaaki
, p. 215 - 220 (2007/10/03)
Keywords: Lipases; Proteases; Acylation; Selective