50680-54-1

Basic information

• Product Name: (dimethylamino)(oxo)acetyl chloride
• CAS NO: 50680-54-1
• Molecular Formula: C₄H₆ClNO₂
• Molecular Weight: 135.5489
• Mol File: 50680-54-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 168.1°C at 760 mmHg
• Flash Point: 55.4°C
• Density: 1.261g/cm³
• Vapor Pressure: 1.65mmHg at 25°C
• Refractive Index: 1.456
• CAS DataBase Reference: (dimethylamino)(oxo)acetyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (dimethylamino)(oxo)acetyl chloride(50680-54-1)
• EPA Substance Registry System: (dimethylamino)(oxo)acetyl chloride(50680-54-1)

Safety Data

• Hazardous Substances Data: 50680-54-1(Hazardous Substances Data)

Upstream product

• 98070-84-9 dichloro-methoxy-acetic acid dimethylamide 
• 98486-39-6 ethoxy-dichloro-acetic acid dimethylamide 
• 79-37-8 oxalyl dichloride 
• 124-40-3 dimethyl amine 
• 506-59-2 N,N-dimethylammonium chloride 
• 32833-96-8 N,N-dimethyloxamic acid 

Downstream Products

• 519-65-3 Dimethylaminooxoessigsaeure-2-acetyl-2-methyl-1-phenylhydrazid 
• 99072-46-5 dimethyl-oxalamic acid-(4-nitro-phenyl ester) 
• 99060-43-2 dimethyl-oxalamic acid phenyl ester 
• 59571-38-9 methyl 2-(dimethylamino)-2-oxoacetate 
• 1039632-13-7 N-(N',N'-dimethyloxamoyl)-3-(S)-(1-(S)-phenylethyl)aminopyrrolidine 
• 1188426-10-9 N-ethyl-N-(2-((4-fluorobenzyl)carbamoyl)-3-hydroxy-4-oxo-6,7,8,9-tetrahydro-7,11-ethanopyrimido[1,2-a]azepin-10(4H)-yl)-N',N'-dimethylethanediamide 
• 1355028-71-5 methyl 3-(benzyloxy)-9-(2-(dimethylamino)-2-oxo-acetamido)-7-morpholino-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylate 

Relevant articles and documents

Copper-Catalyzed Oxalamide-Directed ortho-C-H Amination of Anilines with Alkylamines

A copper-catalyzed oxalamide-directed ortho-C-H amination of anilines has been developed by using 1 atm of air as the sole oxidant. The protocol shows excellent functional group tolerance, and some heterocyclic amines including indole, benzothiophene, benzothiazole, quinoline, isoquinoline, and quinoxaline could be compatible in the reaction. The late-stage diversification of medicinal drugs demonstrates the synthetic utility of this protocol.

Transformation of masked benzyl alcohols to: O -aminobenzaldehydes through C-H activation: A facile approach to quinazolines

Direct transformation of a directing group to important synthetic units would provide a high atom efficiency synthetic approach in synthetic chemistry. Herein, a convenient protocol for the synthesis of o-aminobenzaldehyde and benzoxazole derivatives from benzyl alcohols has been developed by employing (N,N-dimethyl)oxamoyl amide as a directing group in a palladium-catalyzed intramolecular amination. Furthermore, the attached directing center may not only be transformed into the product, but may also be further applied to generate synthetically important quinazoline and quinoline units. Finally, a high atom efficiency one-pot, two-step approach to form quinazolines from benzyl alcohol derivatives has been achieved in good yields, thus demonstrating its high utility.

HIV Integrase Inhibitors

The disclosure generally relates to the novel compounds of formula I, including their salts, which inhibit HIV integrase and prevent viral integration into human DNA. This action makes the compounds useful for treating HIV infection and AIDS. The invention also encompasses pharmaceutical compositions and methods for treating those infected with HIV.