50691-32-2

Basic information

• Product Name: 2-methyl-1-phenyl-1H-pyrrole
• Synonyms: 2-methyl-1-phenyl-1H-pyrrole
• CAS NO: 50691-32-2
• Molecular Weight: 157.215
• Mol File: 50691-32-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-methyl-1-phenyl-1H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl-1-phenyl-1H-pyrrole(50691-32-2)
• EPA Substance Registry System: 2-methyl-1-phenyl-1H-pyrrole(50691-32-2)

Safety Data

• Hazardous Substances Data: 50691-32-2(Hazardous Substances Data)

Upstream product

• 534-22-5 2-methylfuran 
• 62-53-3 aniline 
• 123-76-2 levulinic acid 
• 30186-39-1 N-phenylpyrrole-2-carbaldehyde 
• 22414-24-0 2,5-dihydro-2,5-dimethoxy-2-methylfuran 
• 23132-35-6 levulinanilide 
• 102516-18-7 methyl trans-2-methoxycyclopropyl ketone 
• 33342-99-3 (+/-)-2-methyl-1-phenylpyrrolidine 
• 58518-63-1 2,5-dimethoxy-2-methyl-tetrahydro-furan 

Relevant articles and documents

Mild reduction with silanes and reductive amination of levulinic acid using a simple manganese catalyst

A manganese-based catalytic system using the commercially available complex [Mn(CO)5Br] was studied for the selective reduction of levulinic acid (LA) to 2-methyl-tetrahydrofuran (MTHF). We further studied the production of pyrrolidines via its reductive amination using silanes (phenylsilane and tetramethyldisiloxane). The results showed high efficiency and selectivity for this reaction leading to high yields using mild reaction conditions.

Direct Synthesis of Pyrroles via Heterogeneous Catalytic Condensation of Anilines with Bioderived Furans

Given the wide applications of pyrroles in agriculture, pharmaceuticals, and supramolecular and materials chemistry, a mild and eco-friendly route to produce functionalized pyrroles from bioderived feedstocks is highly desirable. Described herein is a mild and convenient synthesis of pyrroles via direct condensation of an equimolar amount of structurally diverse anilines with biobased furans catalyzed by a simple and efficient solid acid H form zeolite Y catalyst. The protocol tolerates a large variety of functional groups and offers a general and versatile method for scale-up synthesis of a variety of N-substituted pyrrole compounds. Most importantly, the bioactive pyrrole-derived drug pyrvinium, which has lately been confirmed as highly effective in curing colon cancer, can be obtained by this method.

PYRROLE ANTIFUNGAL AGENTS

The invention provides compounds of formula (I), and pharmaceutically and agriculturally acceptable salts thereof; wherein: R1, R2, R3, R4, R5, R6, A1, L1 and n are as defined herein. These compounds and their pharmaceutically acceptable salts are useful in prevention or treatment of a fungal disease. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.