50697-48-8

Basic information

• Product Name: 3-METHYL-4-NITRO-BUTYRALDEHYDE
• Synonyms: 3-METHYL-4-NITRO-BUTYRALDEHYDE;3-methyl-4-nitroButanal
• CAS NO: 50697-48-8
• Molecular Formula: C₅H₉NO₃
• Molecular Weight: 131.12986
• Mol File: 50697-48-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-METHYL-4-NITRO-BUTYRALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-4-NITRO-BUTYRALDEHYDE(50697-48-8)
• EPA Substance Registry System: 3-METHYL-4-NITRO-BUTYRALDEHYDE(50697-48-8)

Safety Data

• Hazardous Substances Data: 50697-48-8(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 15798-64-8 cis-crotonaldehyde 
• 123-73-9 trans-Crotonaldehyde 
• 2985-50-4 3-methyl-4-nitrobutyric acid ethyl ester 
• 10544-63-5 ethyl crotonate 
• 123-73-9 crotonaldehyde 

Downstream Products

• 362510-52-9 2-[benzyl(3-methyl-4-nitrobutyl)amino]ethanol 
• 362510-56-3 4-amino-1-benzyl-5-methylazepan-3-ol 
• 914220-92-1 [benzyl-(3-methyl-4-nitro-butyl)-amino]-acetaldehyde 
• 362510-54-1 1-benzyl-5-methyl-4-nitroazepan-3-ol 
• 362632-39-1 [(S)-1-(1-benzyl-3-hydroxy-5-methylazepan-4-ylcarbamoyl)-3-methylbutyl]carbamic acid tert-butyl ester 
• 1160561-93-2 (4-methyl-5-nitropent-1-enyl)phenylsulfide 

Relevant articles and documents

Synthesis of 4,6-difluoro-5-hydroxy-(α-methyl)tryptamine and 4,6-difluoro-5-hydroxy-(β-methyl)tryptamine as potential selective monoamine oxidase B inhibitors

Condensation of 4-nitro-1-pentanal and 4-nitropentanal 3-methylbutanal with 3,5-difluoro-4-methoxyphenylhydrazine afforded 4,6-difluoro-5-methoxy-3-(2′-nitro)propylindole 4a and 4,6-difluoro-5-methoxy-3-(1′-methyl-2′-nitro)ethylindole 4b, respectively, in one step. Reduction of the nitro group with lithium aluminum hydride followed by removal of the methyl ether with boron tribromide produced the title compounds. They were inactive as MAO B inhibitors.

Reduced graphene oxide supported piperazine in aminocatalysis

Reduced graphene oxide (rGO) has been used as a support for piperazine to provide a heterogeneous bifunctional organocatalyst (rGO-NH) that is able to efficiently promote vintage organic transformations such as Knoevenagel, Michael and aldol reactions. The obtained results suggest a significant role of the support in the course of these reactions. This journal is the Partner Organisations 2014.

Water-compatible iminium activation: Organocatalytic Michael reactions of carbon-centered nucleophiles with enals

(Chemical Equation Presented) A pool of water-compatible catalysts, namely the chiral prolinol-based catalysts 1, has been developed for highly enantioselective C-C bond-forming Michael reactions in water (see scheme). The synthesis of (S)-Rolipram, a type IV phosphodiesterase inhibitor, was also demonstrated.