507-96-0

Basic information

• Product Name: α-campholide
• Synonyms: α-campholide;1,8,8-Trimethyl-3-oxabicyclo[3.2.1]octan-2-one;5,8,8-trimethyl-3-oxabicyclo[3.2.1]octan-4-one
• CAS NO: 507-96-0
• Molecular Formula: C₁₀H₁₆O₂
• Molecular Weight: 168.23
• Mol File: 507-96-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: α-campholide(CAS DataBase Reference)
• NIST Chemistry Reference: α-campholide(507-96-0)
• EPA Substance Registry System: α-campholide(507-96-0)

Safety Data

• Hazardous Substances Data: 507-96-0(Hazardous Substances Data)

Upstream product

• 1126-91-6 1,8,8-trimethyl-2-oxabicyclo[3.2.1]octan-3-one 

Relevant articles and documents

One-Step Annelation. A Convenient Method for the Preparation of Diols, Spirolactones, and Spiroethers from Lactones

1-(ω-Hydroxyalkyl)cyclopentanols and -cyclohexanols were prepared in one step in high yields from butane-1,4-diyl- and pentane-1,5-diylmagnesium dibromides and lactones in tetrahydrofuran.This method was found to be general and applicable to lactones of any size (β, γ, δ, and ε) and structure whether aliphatic, aromatic, bicyclic, or spirocyclic.Evidently important steric hindrance close to the carbonyl group prevents annelation and attack on the second nucleophilic center of the Grignard reagent.Furthermore, in the case of oxetan-2-one one obtains, in additionto the corresponding diol, products resulting from scission of the C-O bond.The diols by appropriate transformation afford new routes to spirolactones and spiroethers.