50763-66-1Relevant articles and documents
+-Nootkatone derivative
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Paragraph 0008; 0009; 0014; 0015, (2017/08/27)
The invention discloses a preparation method for +-nootkatone derivative. The present invention uses the +-nootkatone derivative extracted from cedar leaves as the main material, a chemical compound II is obtained after the restoration through sodium borohydride, the chemical compound II reacts to obtain a chemical compound III and a chemical compound IV through the decomposition of enzymatic dynamics, or decomposes through dynamic kinetics to obtain a chemical compound III with more than 90% yield, a chemical compound V is obtained after hydrolyzing the chemical compound III. The present invention turns the latent chiral ketone group in +-nootkatone into a chirality hydroxy center, and splits further; the present invention has the characteristics of being simple in operation, being high in product yield and with good optics purity.
Highly efficient production of nootkatone, the grapefruit aroma from valencene, by biotransformation
Furusawa, Mai,Hashimoto, Toshihiro,Noma, Yoshiaki,Asakawa, Yoshinori
, p. 1513 - 1514 (2007/10/03)
Nootkatone (2), the most important and expensive aromatic of grapefruit, decreases the somatic fat ratio, and thus its demand is increasing in the cosmetic and fiber sectors. A sesquiterpene hydrocarbon, (+)-valencene (1), which is cheaply obtained from Valencia orange, was biotransformed by the green algae Chlorella species and fungi such as Mucor species, Botryosphaeria dothidea, and Botryodiplodia theobromae to afford nootkatone (2) in high yield.
The Preparation and Microbiological Hydroxylation of the Sesquiterpenoid Nootkatone
Arantes, Simone F.,Farooq, Afgan,Hanson, James R.
, p. 801 - 812 (2007/10/03)
The sesquiterpenoid nootkatone has been prepared from valencene by copper(I) iodide catalysed oxidation with t-butylhydroperoxide and hydroxylated at C-9 by Mucor plumbeus and Cephalosporium aphidicola.