508-64-5Relevant articles and documents
Cardiotonic steroids with additional lactone rings
Makarevich,Kovalenko,Ulesov
experimental part, p. 742 - 745 (2011/02/25)
Stereochemical structural transformations of cardiosteroids to create in them additional lactone rings were studied. Creation of β-lactones by reaction of a 3β-OH group and a 19-carboxylic group to give the corresponding A/B-trans cardiosteroids and creation of β-lactones by reaction of a 5β-OH group and a 19-COOH to give the corresponding A/B-cis steroids were studied. The new biologically active compounds 8(14)-dehydrobovogenin-19-carboxylic acid 3β-O-19-lactone, strophanthidine-19-carboxylic acid 5β-O- 19-lactone, cymarin-19-carboxylic acid 5β-O-19-lactone, convallatoxin-19-carboxylic acid 5β-O-19- lactone, and strophalloside-19-carboxylic acid 5β-O-19-lactone were prepared.