508169-19-5Relevant articles and documents
Enzymatic resolution of new carbonate intermediates for the synthesis of (S)-(+)-zopiclone
Solares, Laura F.,Diaz, Monica,Brieva, Rosario,Sanchez, Victor M.,Bayod, Miguel,Gotor, Vicente
, p. 2577 - 2582 (2002)
The lipase from Candida antarctica B catalyzes the enantioselective hydrolysis of (±)-6-(5-chloropyridin-2-yl)-7-chloromethyloxycarbonyloxy-6,7- dihydro-5H-pyrrolo[3,4-b]pyrazin-5-one, a useful intermediate in the synthesis of (S)-(+)-zopiclone. This enzyme also catalyzes the resolution of the corresponding 2-chloroethylcarbonate derivative.