50878-84-7

Basic information

• Product Name: (E)-1-(2-chlorophenyl)-2-diazonioethenolate
• CAS NO: 50878-84-7
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 180.5911
• Mol File: 50878-84-7.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (E)-1-(2-chlorophenyl)-2-diazonioethenolate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-1-(2-chlorophenyl)-2-diazonioethenolate(50878-84-7)
• EPA Substance Registry System: (E)-1-(2-chlorophenyl)-2-diazonioethenolate(50878-84-7)

Safety Data

• Hazardous Substances Data: 50878-84-7(Hazardous Substances Data)

Usage

Description

(E)-1-(2-chlorophenyl)-2-diazonioethenolate is a chemical compound characterized by the presence of two benzene rings and a diazonium group. It is synthesized through the reaction of 2-chloroaniline with sodium nitrite and hydrochloric acid, resulting in a highly reactive diazonium salt. (E)-1-(2-chlorophenyl)-2-diazonioethenolate is known for its potential applications in organic synthesis and as an intermediate in the production of azo dyes and pigments. However, it requires careful handling due to its tendency to undergo explosive decomposition under specific conditions.

Uses

Used in Organic Synthesis:
(E)-1-(2-chlorophenyl)-2-diazonioethenolate is used as a reagent in organic synthesis for introducing the diazonium group into other molecules. Its high reactivity allows for the creation of a variety of new compounds with potential applications in various industries.
Used in Dye and Pigment Production:
In the chemical industry, (E)-1-(2-chlorophenyl)-2-diazonioethenolate is utilized as an intermediate in the formation of azo dyes and pigments. These dyes and pigments are essential for coloring textiles, plastics, and other materials, contributing to the vibrancy and diversity of colors in various products.
Safety Precautions:
Due to its potential for explosive decomposition, (E)-1-(2-chlorophenyl)-2-diazonioethenolate should be handled with extreme care. Proper safety measures, including the use of protective equipment and controlled environments, should be implemented to minimize the risk of accidents during its synthesis, storage, and use.

Upstream product

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Downstream Products

• 7714-02-5 1,1,2-Tris-methylmercapto-3-<2-chlor-phenyl>-propanon-(3) 
• 40061-54-9 2-chlorophenylacetic acid ethyl ester 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 448922-63-2 1-(2'-chlorophenyl)-2-diazo-2-(triisopropylsilyl)ethanone 
• 896728-55-5 2-diazo-3-(trichloroacetylamino)-1-(2-chlorophenyl)-3-phenylpropan-1-one 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 
• 7714-08-1 <α.β-Bis-methylmercapto-vinyl>-<2-chlor-phenyl>-keton 

Relevant articles and documents

Metal-Free Insertion Reactions of Diazo Carbonyls to Azlactones

Insertion reactions of diazo carbonyls to azlactones in basic conditions have been performed. The developed method allows the preparation of a wide range of oxazole derivatives in yields ranging from 74 to 98%. Different substituents on both azlactone rings and diazo carbonyls do not compromise the methodology, even those containing stereogenic centers. Isotopic labeling experiments revealed the mechanism may proceed through a rare diazo carbonyl activation by an ammonium salt derivative.

One-pot synthesis of polyfunctional pyrazoles: An easy access to α-diazoketones from arylglyoxal monohydrates and tosylhydrazine

A new and efficient method for the generation of α-diazoketones has been developed from arylglyoxal monohydrates and tosylhydrazine at room temperature. 1,3-Dipolar cycloaddition reactions were used to constructing polyfunctional pyrazole derivatives by the reaction of generated α-diazoketones in situ with electron-deficient alkenes, quinones and coumarins in one pot. The one-dimensional molecular packing of 1H-benzo[f]indazole-4,9-dione derivatives along the c direction demonstrated a helical chain formation via N-H?O hydrogen-bonding.

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: Simultaneous optimization of the C(3)-aryl and C(6)-substituents

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (23h) was found to be optimal. (C) 2000 Elsevier Science Ltd. All rights reserved.