50887-69-9

Basic information

• Product Name: OROTIC ACID MONOHYDRATE
• Synonyms: 1,2,3,6-TETRAHYDRO-2,6-DIOXO-4-PYRIMIDINECARBOXYLIC ACID, HYDRATE;2,6-DIOXO-1,2,3,6-TETRAHYDRO-4-PYRIMIDINECARBOXYLIC ACID HYDRATE;2,6-DIOXO-1,2,3,6-TETRAHYDRO-4-PYRIMIDINECARBOXYLIC ACID MONOHYDRATE;2,4-DIHYDROXYPYRIMIDINE-6-CARBOXYLIC ACID HYDRATE;2.4-DIHYDROXYPYRIMIDINE-6-CARBOXYLIC ACID MONOHYDRATE;6-URACILCARBOXYLIC ACID, HYDRATE;OROTIC ACID HYDRATE;OROTIC ACID MONOHYDRATE
• CAS NO: 50887-69-9
• Molecular Formula: C5H6N2O5
• Molecular Weight: 174.11
• EINECS: 200-619-8
• Product Categories: Miscellaneous Natural Products;Heterocyclic Compounds;Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Building Blocks;C4 to C5;Chemical Synthesis;Heterocyclic Building Blocks;Nutrition Research;Other Biochemical;Phytochemicals by Chemical Classification;Pyrimidines;pharmaceutical
• Mol File: 50887-69-9.mol
• Article Data: 0

Chemical Properties

• Melting Point: >300 °C(lit.)
• Boiling Point: 431.3 °C at 760 mmHg
• Flash Point: 214.6 °C
• Appearance: White to off-white/Crystalline Powder
• Density: 1.642 g/cm3
• Vapor Pressure: 7.6E-09mmHg at 25°C
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Aqueous Base (Slightly), DMSO (Slightly)
• Water Solubility: Soluble in water (1.7 mg/ml), and ammonium hydroxide. Insoluble in chloroform.
• Merck: 14,6876
• BRN: 383901
• CAS DataBase Reference: OROTIC ACID MONOHYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: OROTIC ACID MONOHYDRATE(50887-69-9)
• EPA Substance Registry System: OROTIC ACID MONOHYDRATE(50887-69-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: RM3180000
• TSCA: Yes
• Hazardous Substances Data: 50887-69-9(Hazardous Substances Data)

Usage

Description

Orotic acid monohydrate is a white crystalline compound with the chemical formula C5H6N2O4·H2O. It is an intermediate in the biosynthesis of pyrimidine nucleotides and plays a crucial role in the synthesis of uridine monophosphate (UMP), which is a precursor for the nucleic acids RNA and DNA.

Uses

Used in Pharmaceutical Industry:
Orotic acid monohydrate is used as a pharmaceutical intermediate for the preparation of therapeutic agents for chronic obstructive pulmonary disease (COPD) treatment. It helps in improving lung function and reducing inflammation in patients with COPD.
Used in Cosmetic and Food Industry:
Orotic acid monohydrate is used in the cosmetic and food industry as a nutritional supplement and a skin conditioning agent. It helps in maintaining skin hydration and promoting collagen synthesis, which contributes to healthier and more youthful-looking skin.
Used in Pharmaceutical Industry (as a precursor):
Orotic acid monohydrate is also used as a precursor in the synthesis of various pharmaceutical compounds, including antibiotics, antiviral, and anticancer drugs. Its role in the biosynthesis of pyrimidine nucleotides makes it an essential component in the development of these medications.

Purification Methods

It crystallises from water. The anhydrous acid [65-86-1] M 156.1 has m 245-246o(dec). [Nye & Mitchell J Am Chem Soc 69 1382 1947, Beilstein 25 III/IV 1759.]

InChI:InChI=1/C5H4N2O4.H2O/c8-3-1-2(4(9)10)6-5(11)7-3;/h1H,(H,9,10)(H2,6,7,8,11);1H2