509-99-9

Basic information

• Product Name: Neohecogenin
• Synonyms: (25S)-3β-Hydroxy-5α-spirostan-12-one;Neohecogenin
• CAS NO: 509-99-9
• Molecular Formula: C₂₇H₄₂O₄
• Molecular Weight: 444.652
• Mol File: 509-99-9.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Neohecogenin(CAS DataBase Reference)
• NIST Chemistry Reference: Neohecogenin(509-99-9)
• EPA Substance Registry System: Neohecogenin(509-99-9)

Safety Data

• Hazardous Substances Data: 509-99-9(Hazardous Substances Data)

Upstream product

• 79974-44-0 neohecogenin-3-O-β-D-glucopyranoside 
• 4948-48-5 3β-acetoxy-(25R)-5α-spirostan-12-one 
• 38673-27-7 (25R)-5β-spirostan-3,12-dione 
• 6875-60-1 25R-spirost-4-ene-3,12-dione 
• 137853-58-8 YS-VII 
• 137853-58-8 YS-VIII 
• 132998-89-1 Chloromaloside C 
• 132998-87-9 diuranthoside B 
• 133024-11-0 Chloromaloside A 

Downstream Products

• 126-19-2 sarsasapogenin 
• 467-55-0 hecogenin 
• 1426309-53-6 20-oxo-5α-pregnane-3α,12β-diyl 12-acetate 3-benzoate 

Relevant articles and documents

Synthesis of a new cytotoxic cephalostatin/ritterazine analogue from hecogenin and 22-epi-hippuristanol

A new cephalostatin/ritterazine analogue was prepared from the commercially available hecogenin acetate and the natural cytotoxic steroid 22-epi-hippuristanol. The method involved the reductive dimerization of enaminoketones (condensation of α-aminoketones) and condensation between an enaminoketone and an α-hydroxyketone. The new analogue showed higher cytotoxic activity than the cytotoxic 22-epi-hippuristanol against MDA-MB-231, A-549 and HT-29 cultured tumor cell lines.

12-KETO STEROIDAL GLYCOSIDES FROM THE CAUDEX OF YUCCA GLORIOSA

Eight new steroidal glycosides, tentatively named YS-VI, -VII, -VIII, -IX, -X, -XI, -XII, -XIII were isolated from the caudex of Yucca gloriosa along with P-1, YG-2 and YG-3 previously obtained from flowers.The structures of five of these compounds were elucidated as mexogenin 3-O-β-D-glucopyranosyl-(1->2)-β-D-galactopyranoside (YS-VI), gloriogenin 3-O-β-D-glucopyranosyl-(1->2)-3)>-β-D-glucopyranoside (YS-VII) and 3-O-β-D-glucopyransyl-(1->2)-3)>-β-D-galactopyranoside (YS-VIII), manogenin 3-O-β-lycotetraooside (YS-IX) and 3-O-α-L-rhamnopyranosyl-β-lycotetraoside (YS-X), respectively on the basis of chemical and spectral evidence.

STEROIDAL SAPONINS FROM DIURANTHERA MAJOR

In addition to chloromaloside A, three new steroidal saponins, diuranthosides A-C, were isolated from the fresh roots of Diuranthera major.On the basis of chemical and spectroscopic analysis, the structures of diuranthosides A-C were established as neotigogenin 3-O-β-D-glucopyranosyl(1->2)-3)>-β-D-glucopyranosyl(1->4)-β-D-galactopyranoside, neohecogenin 3-O-β-D-glucopyranosyl(1->3)-β-D-xylopyranosyl(1->3)-2)>-β-D-glucopyranosyl(1->4)-β-D-galactopyranoside and neohecogenin 3-O-β-D-glucopyranosyl(1->3)-β-D-glucopyranosyl(1->2)-3)-β-D-xylopyranosyl(1->3)>-β-D-glucopyranosyl(1->4)-β-D-galactopyranoside, respectively.