50907-33-0

Basic information

• Product Name: 3-(2H-TETRAZOL-5-YL)BENZONITRILE
• Synonyms: 3-(2H-TETRAZOL-5-YL)BENZONITRILE
• CAS NO: 50907-33-0
• Molecular Formula: C₈H₅N₅
• Molecular Weight: 171.16
• Mol File: 50907-33-0.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(2H-TETRAZOL-5-YL)BENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2H-TETRAZOL-5-YL)BENZONITRILE(50907-33-0)
• EPA Substance Registry System: 3-(2H-TETRAZOL-5-YL)BENZONITRILE(50907-33-0)

Safety Data

• Hazardous Substances Data: 50907-33-0(Hazardous Substances Data)

Upstream product

• 626-17-5 benzene-1,3-dicarbonitrile 

Relevant articles and documents

Discovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators

The present study describes the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-ylacetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, we identified a tetrazole scaffold that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, we evaluated the compounds in Tier 1 DMPK assays and have identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

Syntheses of 5-substituted 1H-tetrazoles catalyzed by reusable Cu(II)-NaY zeolite from nitriles

Cu(II)-NaY heterogeneous catalyst is used for the synthesis of 5-substituted 1H-tetrazoles by [2+3]-cycloaddition of sodium azide and nitriles. The salient features of this process are low reaction times, mild reaction conditions and high yields. The catalyst is recovered and reused for several cycles with consistent activity.

Cu-MCM-41 nanoparticles: An efficient catalyst for the synthesis of 5-substituted 1H-tetrazoles via [3+2] cycloaddition reaction of nitriles and sodium azide

[3 + 2] cycloaddition reaction of various types of nitriles and sodium azide (NaN 3) were studied in the presence of nano-sized Cu-MCM-41 as an efficient recoverable heterogeneous catalyst. Nano-sized Cu-MCM-41 mesoporous molecular sieves with various Si/Cu molar ratios were synthesized by direct insertion of metal ions at room temperature. The textural properties of the materials have been studied by means of XRD, FTIR, SEM and TEM techniques. Catalytic behavior of Cu-MCM-41 was also investigated by pyridine absorption and potentiometric titration. The reactions data verified characterization results and show that Cu-MCM-41 with Si/Cu molar ratio of 20 has considerably better catalytic activity compared to the other molar ratios. To investigate reusability, the catalyst was recovered by simple filtration and reused for several cycles with consistent activity.