509152-20-9

Basic information

• Product Name: 3-Bromo-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole
• Synonyms: 3-Bromo-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole;3-Bromo-5-methylisoxazole-4-boronic acid pinacol ester
• CAS NO: 509152-20-9
• Molecular Formula: C10H15BBrNO3
• Molecular Weight: 288
• Mol File: 509152-20-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 86-87℃
• Boiling Point: 361℃
• Flash Point: 172℃
• Appearance: /
• Density: 1.37
• PKA: -5.26±0.50(Predicted)
• CAS DataBase Reference: 3-Bromo-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Bromo-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole(509152-20-9)
• EPA Substance Registry System: 3-Bromo-5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoxazole(509152-20-9)

Safety Data

• Hazardous Substances Data: 509152-20-9(Hazardous Substances Data)

Upstream product

• 74213-24-4 N-dibromomethylidenehydroxylamine 
• 347389-75-7 4,4,5,5-tetramethyl-2-(prop-1-yn-1-yl)-1,3,2-dioxaborolane 

Relevant articles and documents

Investigation of the scope of a [3+2] cycloaddition approach to isoxazole boronic esters

The [3+2] cycloaddition reaction of nitrile oxides and alkynylboronates provides direct access to a wide variety of isoxazole boronic esters. Specifically, this technique has been employed to generate trisubstituted isoxazole 4-boronates and disubstituted isoxazoles where the boronic ester moiety can be installed at C-4 or C-5 with high levels of regiocontrol. The application of this methodology in the synthesis of non-steroidal antiinflammatory agents is also described.