50916-34-2

Basic information

• Product Name: Benzonitrile, 3-(1-oxopropyl)-
• Synonyms: 3'-Cyano-propiophenon;3-propionyl-benzonitrile;3-cyanopropiophenone;3'-cyanopropiophenone;3-Cyanopropiophenon;3-cyano propiophenone
• CAS NO: 50916-34-2
• Molecular Formula: C10H9NO
• Molecular Weight: 159.188
• Mol File: 50916-34-2.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 3-(1-oxopropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 3-(1-oxopropyl)-(50916-34-2)
• EPA Substance Registry System: Benzonitrile, 3-(1-oxopropyl)-(50916-34-2)

Safety Data

• Hazardous Substances Data: 50916-34-2(Hazardous Substances Data)

Usage

Description

Benzonitrile, 3-(1-oxopropyl)-, also known as 3-propanoylbenzonitrile, is an organic compound with the molecular formula C10H9NO. It is a derivative of benzonitrile, featuring a propanoyl group attached to the third carbon of the benzene ring. Benzonitrile, 3-(1-oxopropyl)is known for its potential applications in the pharmaceutical and chemical industries due to its unique structural properties.

Uses

Used in Pharmaceutical Industry:
Benzonitrile, 3-(1-oxopropyl)is used as an intermediate compound for the synthesis of pyrimidinediones, which are apelin receptor agonists. These agonists play a crucial role in various physiological processes, including blood pressure regulation, body weight control, and energy homeostasis. The development of apelin receptor agonists has significant potential in the treatment of conditions such as hypertension, heart failure, and obesity.

Upstream product

• 19829-31-3 1-(3-bromophenyl)-1-propanone 
• 544-92-3 copper(I) cyanide 
• 1197-05-3 1-(3-amino-phenyl)-propan-1-one 
• 151-50-8 potassium cyanide 
• 6952-59-6 3-cyanobromobenzene 
• 79-03-8 propionyl chloride 
• 34841-35-5 3'-chloro-propiophenone 
• 17408-16-1 3'-nitropropiophenone 

Downstream Products

• 1212967-40-2 (S)-3-(1-aminopropyl)benzonitrile 
• 1440663-52-4 (E)-3-(3-(5-methylthiophen-2-yl)acryloyl)benzonitrile 
• 1415829-33-2 C₁₂H₉N₃O₂ 
• 1415829-37-6 ethyl 5-(3-cyanophenyl)-4-methyl-1H-pyrazole-3-carboxylate 
• 1415829-33-2 5-(3-cyanophenyl)-4-methyl-1H-pyrazole-3-carboxylic acid 
• 1372393-76-4 C₁₆H₁₀N₂O₃ 
• 86042-92-4 3-((2R,3S)-2,3-Dimethyl-6-oxo-tetrahydro-pyran-2-yl)-benzonitrile 
• 86042-92-4 3-((2R,3R)-2,3-Dimethyl-6-oxo-tetrahydro-pyran-2-yl)-benzonitrile 
• 154320-61-3 3-benzoyl-α-chloro-propiophenone 
• 72563-47-4 3-propionylbenzoyl chloride 
• 66952-39-4 1-(3-benzoylphenyl)propan-1-one 
• 166186-73-8 3-<2-(tert-butoxycarbonyl)-1-ethyl-3-(2-hydroxyphenyl)-3-oxopropyl>benzoic acid tert-butyl ester 
• 166186-74-9 3-<1-(4-hydroxy-2-oxo-2H-chromen-3-yl)propyl>benzoic acid 
• 166186-72-7 3-<1-<(tert-butoxycarbonyl)methyl>propyl>benzoic acid tert-butyl ester 

Relevant articles and documents

APELIN RECEPTOR AGONISTS AND METHODS OF USE

The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.

A straightforward and versatile protocol for the direct conversion of benzylic azides to ketones and aldehydes

The synthesis of carbonyl compounds from benzylic azides through benzylideneamides is described for the first time. NaH-mediated activation of benzyl azides allows a rapid water-promoted oxidation under a facile protocol with good yields.

PIPERIDINE-AMIDE DERIVATIVES

The invention is concerned with novel piperidine-amide derivatives of formula (I) wherein R1, R2, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These comp