50972-63-9

Basic information

• Product Name: 3-chloro-4-hydroxybenzeneethanol
• Synonyms: 3-chloro-4-hydroxybenzeneethanol
• CAS NO: 50972-63-9
• Molecular Weight: 172.611
• Mol File: 50972-63-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-chloro-4-hydroxybenzeneethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-4-hydroxybenzeneethanol(50972-63-9)
• EPA Substance Registry System: 3-chloro-4-hydroxybenzeneethanol(50972-63-9)

Safety Data

• Hazardous Substances Data: 50972-63-9(Hazardous Substances Data)

Upstream product

• 501-94-0 p-hydroxyphenethyl alcohol 
• 33697-81-3 (3-chloro-4-hydroxy-phenyl)-acetic acid 

Downstream Products

• 346730-59-4 C₂₀H₁₅ClN₂O₁₀S₂ 
• 140893-20-5 3-(4-chlorophenylsulphonyl)-2-(4-ethoxycarbonylmethoxy-3-chlorobenzyl)thiazolidine 
• 140893-13-6 2-(4-ethoxycarbonylmethoxy-3-chlorobenzyl)thiazolidine 
• 1026684-62-7 ethyl 2-chloro-4-formylmethylphenoxyacetate 
• 156781-07-6 ethyl 2-[2-chloro-4-(2-hydroxyethyl)phenoxy]acetate 

Relevant articles and documents

Facile one-pot synthesis of tetrahydroisoquinolines from amino acids via hypochlorite-mediated decarboxylation and Pictet-Spengler condensation

A convenient method for oxidative decarboxylation of α-amino acids is presented. The aldehyde products may be isolated or converted to tetrahydroisoquinolines by addition of dopamine via Pictet-Spengler reaction. Racemic products are generated by phosphate buffer >300 mM to maximize regioselectivity. (S)-Enantiomer products are generated by norcoclaurine synthase reaction in maleic acid buffer to minimize chemical background reaction.

Synthesis and evaluation of novel thiazolidine derivatives as thromboxane A2 receptor antagonists

A series of 3-benzoyl or 3-phenylsulfonyl-2-substituted thiazolidine derivatives were synthesized, and evaluated for their thromboxane A2 (TXA2) receptor-antagonizing effect on (15S)-15-hydroxy-11α,9α- (epoxymethano)prosta-5(Z),13(E)-dienoic acid (U-46619)-induced aggregation of rabbit platelet-rich plasma (PRP). A simple 2-arylthiazolidine derivative, 3- benzoyl-2-(4-hydroxy-3-methoxyphenyl)thiazolidine (5a), showed mild TXA2 receptor antagonist activity. Modification of 5a led to 2-chloro-4-[3-(4- chlorophenylsulfonyl)thiazolidin-2-ylmethyl]phenoxyaretic acid (29d), which showed 10 times more potent TXA2 receptor antagonist activity than 5a.