50996-12-8

Basic information

• Product Name: 6-amino-5-(nitro)-1-methylpyrimidine-2,4(1H,3H)-dione
• Synonyms: 6-amino-5-(nitro)-1-methylpyrimidine-2,4(1H,3H)-dione
• CAS NO: 50996-12-8
• Molecular Formula: C5H6N4O4
• Molecular Weight: 186.12554
• Mol File: 50996-12-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 6-amino-5-(nitro)-1-methylpyrimidine-2,4(1H,3H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-amino-5-(nitro)-1-methylpyrimidine-2,4(1H,3H)-dione(50996-12-8)
• EPA Substance Registry System: 6-amino-5-(nitro)-1-methylpyrimidine-2,4(1H,3H)-dione(50996-12-8)

Safety Data

• Hazardous Substances Data: 50996-12-8(Hazardous Substances Data)

Upstream product

• 183987-64-6 4-methyl-1-oxy-4H-[1,2,5]thiadiazolo[3,4-d]pyrimidine-5,7-dione 
• 183987-65-7 4-methyl-1-oxy-4H-[1,2,5]selenadiazolo[3,4-d]pyrimidine-5,7-dione 
• 6972-77-6 N-cyanoacetyl-N'-methyl-urea 
• 2434-53-9 6-amino-1-methyluracil 

Downstream Products

• 6972-82-3 5,6-diamino-1-methyluracil 

Relevant articles and documents

Synthesis and lipid-lowering evaluation of 3-methyl-1 H-purine-2,6-dione derivatives as potent and orally available anti-obesityagents

Obesity accompanied with metabolic disorder is often complicated with a strong link of dyslipidemia and insulin resistance, whose indicator is the excess accumulation of triglycerides (TG) in cells. Consideration the idea of lipid-lowering and improving insulin resistance, 34 novel compounds by combination the xanthine scaffold with the chain of Rosiglitazone have been synthesized. Among them, several compounds showed efficiency on reducing TG in 3T3-L1 adipoctyes, and 11c exhibited the most optimal capacity in lipid-lowering and improving obese clinical symptoms in DIO mice. Furthermore, the hydrochloride of 11c (11c·HCl) showed excellent bioavailability, 58.94%, over 2 folds than that (28.03%) of 11c, and the anti-obesity effect of 11c·HCl at 50 mg/kg dose was better than that of Metformin at 150 mg/kg dose in DIO mice, almost reversed HFD to a normal level. Thus, 11c·HCl might be a potent and orally available anti-obesity agent via alleviating the obese clinical symptoms, body fat, improving serum parameters and insulin resistance and TG clearance in liver.