50997-19-8

Basic information

• Product Name: maleylphenylalanine methyl ester
• Synonyms: maleylphenylalanine methyl ester
• CAS NO: 50997-19-8
• Molecular Formula: C₁₄H₁₅NO₅
• Molecular Weight: 277.27
• Mol File: 50997-19-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 536.7°Cat760mmHg
• Flash Point: 278.4°C
• Appearance: /
• Density: 1.264g/cm³
• Vapor Pressure: 2.39E-12mmHg at 25°C
• Refractive Index: 1.556
• CAS DataBase Reference: maleylphenylalanine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: maleylphenylalanine methyl ester(50997-19-8)
• EPA Substance Registry System: maleylphenylalanine methyl ester(50997-19-8)

Safety Data

• Hazardous Substances Data: 50997-19-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H15NO5/c1-20-14(19)11(9-10-5-3-2-4-6-10)15-12(16)7-8-13(17)18/h2-8,11H,9H2,1H3,(H,15,16)(H,17,18)/b8-7-/t11-/m0/s1

Upstream product

• 108-31-6 maleic anhydride 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 2577-90-4 (D)-Phenylalaninmethylester 
• 2577-90-4 L-phenylalanine methyl ester 

Downstream Products

• 57079-18-2 N-maleyl-L-phenylalanine 
• 62205-63-4 methyl N,N-maleoyl-L-phenylalaninate 
• 144965-45-7 N-Benzyl-α-aspartyl-(β-benzyl)-(D)-phenylalaninmethylester 
• 144965-45-7 N-Benzyl-α-aspartyl-(β-benzyl)-(L)-phenylalaninmethylester 

Relevant articles and documents

Synthesis and properties of chiral N,N-maleoyl derivatives and Diels-Alder reactions with cyclopentadiene

Maleyl amino acid derivatives were prepared from maleic anhydride and cyclized by reaction with ZnCl2 and hexamethyldisilazane yielding maleoyl derivatives. These derivatives were used as dienophiles in cycloadditions with cyclopentadiene. The

Synthetic and NMR-Spectroscopic Investigation of Benzylamine Addition to N-Maleylamino Acid Derivatives

During the addition of amines to maleylamino acids in general β-amino derivatives are formed.In order to change the reactivity within the vinylogous maleyl system we introduced the β-benzylester group into the starting compound N-(cis-β-carboxyacryloyl)-phenylalanine methylester 1.The obtained benzylester 2 is adding benzylamine in α-position yielding N-benzyl-α-aspartyl(β-benzyl)-phenylalanine methylester 4.The addition reaction was investigated by 1H-NMR-spectroscopy.The structures of the compounds have been confirmed by elemental analysis, IR, 1H-NMR and 13C-NMR spectroscopy.Keywords. α-Aspartyl peptides; N-Maleylamino acid derivatives; Nucleophilic addition.