510-62-3 Usage
General Description
3β,14-Dihydroxy-19-oxobufa-4,20,22-trienolide is a naturally occurring bufadienolide, a class of steroid compounds found in plants and animals. It is known for its potent biological activities, including anti-tumor, anti-inflammatory, and cardioactive effects. 3β,14-Dihydroxy-19-oxobufa-4,20,22-trienolide has been isolated from various plant species and has been studied for its potential pharmacological applications. Its unique chemical structure and diverse bioactivities make it an interesting target for further research and potential development of pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 510-62-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,1 and 0 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 510-62:
(5*5)+(4*1)+(3*0)+(2*6)+(1*2)=43
43 % 10 = 3
So 510-62-3 is a valid CAS Registry Number.
InChI:InChI=1/C24H30O5/c1-22-9-7-19-20(4-3-16-12-17(26)6-10-23(16,19)14-25)24(22,28)11-8-18(22)15-2-5-21(27)29-13-15/h2,5,12-14,17-20,26,28H,3-4,6-11H2,1H3/t17-,18+,19?,20?,22+,23+,24-/m0/s1
510-62-3Relevant articles and documents
Antiproliferative homoisoflavonoids and bufatrienolides from Urginea depressa
Dai, Yumin,Harinantenaina, Liva,Brodie, Peggy J.,Goetz, Michael,Shen, Yongchun,Tendyke, Karen,Kingston, David G. I.
, p. 865 - 872 (2013/06/27)
Investigation of the South African plant Urginea depressa Baker (Asparagaceae Juss.) for antiproliferative activity against the A2780 ovarian cancer cell line led to the isolation of the six new homoisoflavonoids urgineanins A-F (1-6), the two known bufatrienolides 7 and 9, and the new bufatrienolides urginins B and C (8 and 10). Structures were elucidated based on analysis of their 1D and 2D NMR spectra, electronic circular dichroism, and mass spectrometric data. Five of the six new homoisoflavonoids had good antiproliferative activity against the A2780 ovarian cancer, A2058 melanoma, and H522-T1 human non-small-cell lung cancer cells, and urgineanin A (1) had submicromolar activity against all three cell lines. The four bufatrienolides 7-10 had strong antiproliferative activity against the same cell line, with IC50 values of 24.1, 11.2, 111, and 40.6 nM, respectively.
