510-98-5

Basic information

• Product Name: (1S,4aα)-Decahydro-2α,5,5,8aβ-tetramethyl-1-naphthalenemethanol
• Synonyms: 1-Naphthalenemethanol, decahydro-2,5,5,8a-tetramethyl-, (1S,2R,4aS,8aS)-
• CAS NO: 510-98-5
• Molecular Formula: C₁₅H₂₈O
• Molecular Weight: 224.38222
• Mol File: 510-98-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 60-62 °C
• Boiling Point: 292.8±8.0 °C(Predicted)
• Appearance: /
• Density: 0.896±0.06 g/cm3(Predicted)
• PKA: 14.99±0.10(Predicted)
• CAS DataBase Reference: (1S,4aα)-Decahydro-2α,5,5,8aβ-tetramethyl-1-naphthalenemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1S,4aα)-Decahydro-2α,5,5,8aβ-tetramethyl-1-naphthalenemethanol(510-98-5)
• EPA Substance Registry System: (1S,4aα)-Decahydro-2α,5,5,8aβ-tetramethyl-1-naphthalenemethanol(510-98-5)

Safety Data

• Hazardous Substances Data: 510-98-5(Hazardous Substances Data)

Upstream product

• 54632-04-1 albicanol 
• 468-68-8 (8aS)-(-)-drimenol 
• 112853-89-1 Methanesulfonic acid (1S,2S,8aS)-2,5,5,8a-tetramethyl-decahydro-naphthalen-1-ylmethyl ester 
• 112853-90-4 Toluene-4-sulfonic acid (1S,2S,8aS)-2,5,5,8a-tetramethyl-decahydro-naphthalen-1-ylmethyl ester 
• 52617-99-9 (+)-drimane-8,11-diol 
• 468-68-8 (-)-drimenol 
• 106-28-5 Farnesol 
• 34175-53-6 (S,2E,6E)-9-(3,3-dimethyloxiran-2-yl)-3,7-dimethylnona-2,6-dien-1-ol 
• 4128-17-0 (2E,6E)-farnesyl acetate 
• 130790-62-4 (R,2E,6E)-10,11-dihydroxy-3,7,11-trimethyldodeca-2,6-dienyl acetate 
• 93861-36-0 essigsaeure-<(E,E,10S)-10,11-epoxy-3,7,11-trimethyl-2,6-dodecadien-1-yl>ester 
• 856683-41-5 ((2S,4aS,5S,8aR)-decahydro-2-hydroxy-1,1,4a-trimethyl-6-methylenenaphthalen-5-yl)methyl acetate 
• 83679-71-4 [(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]methyl acetate 
• 468-68-8 (-)-drimenol 

Downstream Products

• 5951-58-6 8α(H)-drimane 

Relevant articles and documents

Enantioselective Total Synthesis of (–)-Siphonodictyal B and (+)-8-epi-Siphonodictyal B with Phosphatidylinositol 3-Kinase α (PI3Kα) Inhibitory Activity

The biologically interesting marine meroterpenoids (–)-siphonodictyal B and (+)-8-epi-siphonodictyal B were efficiently synthesized in 29–40 % overall yield in a longest linear sequence of 11 steps, starting from commercially available (+)-sclareolide. The synthesis involved the following crucial steps: (i) stereodivergent hydrogenation of a homoallylic decalin alcohol to install the requisite C8 stereogenic centre present in the decalin fragments; (ii) coupling of the decalin fragments with an aromatic moiety to assemble the desired carbon skeletons; and (iii) deprotection from multiple O-protective groups on the aromatic ring to complete the project synthesis. Both (–)-siphonodictyal B and (+)-8-epi-siphonodictyal B showed PI3Kα inhibitory activity, with potencies comparable to that of liphagal, a naturally occurring PI3Kα inhibitor. New structure–activity relationships for this class of marine meroterpenoids were also revealed.

Synthesis of the Sesquiterpenes Albicanol, Drimanol, and Drimanic Acid, and the Marine Sesquiterpene Hydroquinone Deoxyspongiaquinol

A TiIII-mediated radical cyclization cascade has been used for the synthesis of the sesquiterpenes (+)-albicanol, (+)-drimanol, and (+)-drimanic acid. Starting from all-trans-farnesol, (+)-albicanol could be prepared in seven steps in an overal

Fungal Metabolites. Part 5. Uvidins, New Drimane Sesquiterpenes from Lactarius uvidus Fries

Uvidin A (IIa) and uvidin B (IIc) along with (-)-drimenol have been isolated from Lactarius uvidus Fries (Basidiomycetes).The structure and the stereochemistry of the two uvidins have been determined both by spectroscopic data and chemical reactions.Compound (IIa) has been correlated with (+)-drimanol (VIII) by transformations into (VI) and then (VII).Reactions and spectroscopic data are discussed.