5100-57-2

Basic information

• Product Name: ethyl 2-(quinolin-2-yl)acetate
• Synonyms: ethyl 2-(quinolin-2-yl)acetate;2-Quinolineacetic acid, ethyl ester;Quinolin-2-ylacetic acid ethyl ester
• CAS NO: 5100-57-2
• Molecular Formula: C₁₃H₁₃NO₂
• Molecular Weight: 215
• Mol File: 5100-57-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 147-150 °C(Press: 5 Torr)
• Appearance: /
• Density: 1.156±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.18±0.48(Predicted)
• CAS DataBase Reference: ethyl 2-(quinolin-2-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(quinolin-2-yl)acetate(5100-57-2)
• EPA Substance Registry System: ethyl 2-(quinolin-2-yl)acetate(5100-57-2)

Safety Data

• Hazardous Substances Data: 5100-57-2(Hazardous Substances Data)

Usage

General Description

Ethyl 2-(quinolin-2-yl)acetate is a chemical compound with the molecular formula C14H13NO2. It is a member of the class of quinolinyl acetates and is commonly used as a building block in organic synthesis. ethyl 2-(quinolin-2-yl)acetate has a bright yellow color with a characteristic odor. Ethyl 2-(quinolin-2-yl)acetate is often used as a flavor and fragrance ingredient in the food and cosmetic industries. It can also be used as a reagent in chemical reactions to create more complex molecules. Additionally, this compound has been studied for its potential pharmacological activities, including its anti-inflammatory and anti-fibrotic properties.

Upstream product

• 91-63-4 2-methylquinoline 
• 591-51-5 phenyllithium 
• 6560-83-4 2-iodoquinoline 
• 5764-82-9 bromo(2-ethoxy-2-oxoethyl)zinc 
• 612-62-4 2-Chloroquinoline 

Downstream Products

• 1011-50-3 2-quinolin-2-yl-ethanol 
• 117871-91-7 3-Phenyl-4-thioxo-4H-pyrido[1,2-b]isoquinoline-1-carboxylic acid ethyl ester 
• 117840-92-3 [4-Phenyl-[1,2]dithiol-(3E)-ylidene]-quinolin-2-yl-acetic acid ethyl ester 
• 104037-38-9 D 1997 
• 757249-10-8 N-(2-[2]quinolyl-ethyl)-formamide 
• 476659-82-2 ethyl {4-[(diethylamino)carbonyl]-2-nitrophenyl} (quinolin-2(1H)-ylidene)acetate 
• 1430074-92-2 ethyl 1-phenylimidazo[1,5-α]quinoline-3-carboxylate 
• 1616391-91-3 ethyl 2-phenylpyrrolo[1,2-a]quinoline-3-carboxylate 
• 1616391-93-5 ethyl 2-p-tolylpyrrolo[1,2-a]quinoline-3-carboxylate 
• 1616391-95-7 ethyl 2-(4-(dimethylamino)phenyl)pyrrolo[1,2-a]quinoline-3-carboxylate 
• 1616391-97-9 ethyl 2-(4-hydroxyphenyl)pyrrolo[1,2-a]quinoline-3-carboxylate 
• 1616391-99-1 ethyl 2-(3,4-dimethoxyphenyl)pyrrolo[1,2-a]quinoline-3-carboxylate 
• 1616392-01-8 ethyl 2-(3-methoxyphenyl)pyrrolo[1,2-a]quinoline-3-carboxylate 
• 1616392-03-0 ethyl 2-(4-fluorophenyl)pyrrolo[1,2-a]quinoline-3-carboxylate 

Relevant articles and documents

Coupling of Reformatsky Reagents with Aryl Chlorides Enabled by Ylide-Functionalized Phosphine Ligands

The coupling of aryl chlorides with Reformatsky reagents is a desirable strategy for the construction of α-aryl esters but has so far been substantially limited in the substrate scope due to many challenges posed by various possible side reactions. This limitation has now been overcome by the tailoring of ylide-functionalized phosphines to fit the requirements of Negishi couplings. Record-setting activities were achieved in palladium-catalyzed arylations of organozinc reagents with aryl electrophiles using a cyclohexyl-YPhos ligand bearing an ortho-tolyl-substituent in the backbone. This highly electron-rich, bulky ligand enables the use of aryl chlorides in room temperature couplings of Reformatsky reagents. The reaction scope covers diversely functionalized arylacetic and arylpropionic acid derivatives. Aryl bromides and chlorides can be converted selectively over triflate electrophiles, which permits consecutive coupling strategies.