51014-29-0 Usage
Description
Isocorynoxeine is a bioactive oxindole alkaloid found in the Uncaria species and is the first reported occurrence of the base in nature, specifically in the leaves of Mitragyna rotundifolia grown in Burma. Its structure has been established through spectroscopic investigations and is known for its wide array of beneficial cardiovascular and cardiocerebral vascular system effects.
Uses
Used in Pharmaceutical Industry:
Isocorynoxeine is used as a bioactive compound for its cardiovascular and cardiocerebral vascular system benefits. It contributes to the development of potential therapeutic agents targeting various cardiovascular and cerebrovascular conditions due to its wide array of beneficial effects.
Used in Cardiovascular Applications:
Isocorynoxeine is used as a therapeutic agent for improving cardiovascular health and treating related conditions. Its beneficial effects on the cardiovascular and cardiocerebral vascular system make it a promising candidate for the development of new treatments and medications in this field.
Used in Cerebrovascular Applications:
Isocorynoxeine is used as a therapeutic agent for enhancing the health of the brain's blood vessels and treating cerebrovascular conditions. Its positive impact on the cardiocerebral vascular system highlights its potential in developing treatments for various brain-related vascular disorders.
References
Houghton, Shellard, Planta Med., 26, 104 (1974)
Check Digit Verification of cas no
The CAS Registry Mumber 51014-29-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,0,1 and 4 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 51014-29:
(7*5)+(6*1)+(5*0)+(4*1)+(3*4)+(2*2)+(1*9)=70
70 % 10 = 0
So 51014-29-0 is a valid CAS Registry Number.
InChI:InChI=1/C22H26N2O4/c1-4-14-12-24-10-9-22(17-7-5-6-8-18(17)23-21(22)26)19(24)11-15(14)16(13-27-2)20(25)28-3/h4-8,13-15,19H,1,9-12H2,2-3H3,(H,23,26)/b16-13+/t14-,15-,19-,22-/m0/s1
51014-29-0Relevant articles and documents
Total synthesis of the spirocyclic oxindole alkaloids corynoxine, corynoxine B, corynoxeine, and rhynchophylline
Wanner, Martin J.,Ingemann, Steen,Van Maarseveen, Jan H.,Hiemstra, Henk
, p. 1100 - 1106 (2013/03/29)
Racemic total syntheses of four spirocyclic oxindole alkaloids are reported. The general starting material was an N-2-butenylated 2-hydroxytryptamine, which underwent a base-mediated Mannich spirocyclisation with a functionalised aldehyde to generate the C-ring. The second key step was a Pd-catalysed cyclisation of an α-keto ester enolate (in the original aldehyde) onto an allylic carbonate (in the N-substituent) to form the D-ring. The stereoselectivities of the key steps were moderate, but the isomers were readily purified, so that the natural products could be conveniently prepared, three of them for the first time. Racemic total syntheses of the four title spirocyclic oxindole alkaloids are reported starting from 4-hydroxytryptamine. The key steps were a base-mediated Mannich spirocyclisation to form the C-ring, and a Pd-catalysed cyclisation of a keto ester enolate onto an allylic carbonate to form the D-ring. Thus, convenient syntheses of the alkaloids were achieved, for three of them for the first time. Copyright
