51026-98-3 Usage
Description
Butanoic acid, 2-nitro-3-oxo-, ethyl ester, also known as Ethyl Nitroacetoacetate, is an organic compound that serves as an intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its ester functional group and nitro group, which contribute to its reactivity and potential applications in the chemical and pharmaceutical industries.
Uses
Used in Pharmaceutical Synthesis:
Butanoic acid, 2-nitro-3-oxo-, ethyl ester is used as an intermediate in the synthesis of N-Hydroxy Eltrombopag (H825795), a derivative compound of Eltrombopag (508000). Eltrombopag is an agonist of the Thrombopoietin (Tpo) receptor and is utilized as a treatment for thrombocytopenia, a condition characterized by a low platelet count in the blood.
In the pharmaceutical industry, Ethyl Nitroacetoacetate plays a crucial role in the development of new drugs and therapies, particularly for conditions like thrombocytopenia. Its unique chemical structure allows it to be a versatile building block in the synthesis of complex molecules with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 51026-98-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,0,2 and 6 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 51026-98:
(7*5)+(6*1)+(5*0)+(4*2)+(3*6)+(2*9)+(1*8)=93
93 % 10 = 3
So 51026-98-3 is a valid CAS Registry Number.
51026-98-3Relevant articles and documents
Ti(iv)-catalyzed cascade synthesis of tetrahydrofuro[3,2-d]oxazole from arene-1,4-diones
Li, Gang,Li, Li,Huang, Haihong,Yin, Dali
, p. 4418 - 4421 (2015)
A tetrahydrofuro[3,2-d]oxazole scaffold was synthesized efficiently and stereoselectively. The tandem ionic hydrogenation, ketalization, and intramolecular cyclization of arene-1,4-diones with a combination of TiCl4/Et3SiH give facile access to tetrahydrofuro[3,2-d]oxazole derivatives in good yields at room temperature.
Synthesis of α-functional nitro compounds by the nitration of activated carbonyl compounds in a two-phase system
Kislyi, V. P.,Laikhter, A. L.,Ugrak, B. I.,Semenov, V. V.
, p. 70 - 74 (2007/10/02)
2-Nitro-1,3-dicarbonyl and α-nitromonocarbonyl compounds were synthesized in the yields variyng from moderate (30percent) to nearly quantitative by the nitration of β-dicarbonyl compounds in a two-phase system: sulfuric/nitric acid mixture - chloroform at -10 - 10 deg C.The use of phase transfer conditions made it possible to avoid the formation of furoxans as by-products and to simplify the isolation of products.This method is quite common for preparing various α-functional nitro compounds including those containing a CF3-group. - Key words: nitration, α-functional nitro compounds.
