5103-42-4

Basic information

• Product Name: HYDRINDANTIN
• Synonyms: 2,2'-Dihydroxy-2,2'-bi[1H-indene]-1,1',3,3'(2H,2'H)-tetrone;Reduced ninhydrin;2-hydroxy-2-(2-hydroxy-1,3-diketo-indan-2-yl)indane-1,3-quinone;2-hydroxy-2-(2-hydroxy-1,3-dioxo-inden-2-yl)indene-1,3-dione;2-hydroxy-2-(2-hydroxy-1,3-dioxoinden-2-yl)indene-1,3-dione;Hydrindantin (reduced form of ninhydrin);NSC 83617;[2,2'-Bi-1H-indene]-1,1',3,3'(2H,2'H)-tetrone,2,2'-dihydroxy-
• CAS NO: 5103-42-4
• Molecular Formula: C₁₈H₁₀O₆
• Molecular Weight: 322.27
• EINECS: 225-823-4
• Mol File: 5103-42-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 252 °C (dec.)(lit.)
• Boiling Point: 380.9°C (rough estimate)
• Flash Point: 339.8°C
• Appearance: /
• Density: 1.718±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 5.55E-16mmHg at 25°C
• Refractive Index: 1.4800 (estimate)
• PKA: 8.89±0.20(Predicted)
• Merck: 4775
• CAS DataBase Reference: HYDRINDANTIN(CAS DataBase Reference)
• NIST Chemistry Reference: HYDRINDANTIN(5103-42-4)
• EPA Substance Registry System: HYDRINDANTIN(5103-42-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39
• WGK Germany: 2
• Hazardous Substances Data: 5103-42-4(Hazardous Substances Data)

Usage

Uses

Used in the determination of amino acids.

InChI:InChI=1/C18H10O6/c19-13-9-5-1-2-6-10(9)14(20)17(13,23)18(24)15(21)11-7-3-4-8-12(11)16(18)22/h1-8,23-24H

Upstream product

• 485-47-2 indan-1,2,3-trione hydrate 
• 3674-33-7 2-nitro-1,3-indanedione 
• 64-19-7 acetic acid 
• 20207-47-0 3-(2-Hydroxy-aethoxy)-2-hydroxy-indenon-⁽¹⁾ 
• 56-41-7 L-alanin 
• 56-45-1 L-serin 
• 70-47-3 L-asparagine 
• 63-91-2 L-phenylalanine 
• 56-40-6 glycine 
• 50616-96-1 9-(2-Hydroxy-1,3-dioxo-2-indanyl)-9-methoxyfluoren 
• 26976-58-9 2-hydroxy-indan-1,3-dione 
• 73636-26-7 2-Acetoxy-1,3-indandione 
• 5103-44-6 Formylhydrindantin 
• 5103-45-7 Acetylhydrindantin 

Downstream Products

• 85-44-9 phthalic anhydride 
• 6940-95-0 [2,2']biindenyl-1,3,1',3'-tetraone 
• 75-07-0 acetaldehyde 

Relevant articles and documents

Kinetics of interaction of histidine and histidine methyl ester with ninhydrin in micellar media

Kinetics of the interaction of histidine and histidine methyl ester with ninhydrin under varying concentrations of reactants, anionic (sodium dodecyl sulphate, SDS), cationic (cetyltrimethylammonium bromide, CTAB) and non-ionic (Triton X-100, TX-100) micelles have been carried out. Rate of the reaction was found to be independent of the initial concentration of histidine (and histidine methyl ester) but was dependent on [Ninhydrin]. The SDS micelles had no effect on the rate of the reaction. In the presence of the CTAB micelles a small enhancement in the rate was observed. The rate - [CTAB] profile showed that the increase in [CTAB] increased the rate up to a maximum value and a further increase had a decreasing effect on the rate. The rate was enhanced by TX-100 also but, unlike CTAB micelles, TX-100 possessed a curve without peak for the rate - [TX-100] profile. The following rate equation was obeyed by the reaction in CTAB and TX-100 micelles: 1kΨ = kw[N]T + (km KS - kw) [Dn] MNS/1 + KS [Dn] Values of kw, km, and KS were evaluated and are reported herein.

Effect of organic solvents (methylcellosolve, dimethylsulfoxide, acetonitrile and 1-propanol) on the tryptophan-ninhydrin reaction - A kinetic approach

Kinetics of the tryptophan-ninhydrin reaction at a constant [Triton X-100] (=50.0 × 10-3 mol dm-3) and pH (=5.0), maintained by CH3COONa-CH3COOH, in presence of different organic solvents, i.e. methylcellosolve, dimethylsulfoxide, acetonitrile and 1-propanol, has been studied spectrophotometrically at 40°C. In each case, the pseudo-first-order rate constant increases with increase in the proportion of organic solvent. The catalytic role of solvents has been discussed in terms of increasing the solubility of Ruhemann's purple (the product) in the solvents and blocking the side reaction. Other reasons for the catalytic role of solvents have also been discussed.

Studies on the kinetics and mechanism of interaction of α-amino acids with ninhydrin

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