51034-65-2 Usage
Classification
Nucleotide analog
Structure
Derivative of cytidine with an azide group at the 2' position of the deoxyribose sugar
Role
Mimics natural nucleotides in DNA and RNA
Importance
Significant in biochemistry and molecular biology research
Applications
Study of nucleotide analog effects on DNA replication and transcription processes
Tool for investigating mechanisms of antiviral and anticancer drugs
Potential therapeutic applications as an antiviral agent
Specific Usage
Inhibiting viral replication
Field of Use
Biochemistry, molecular biology
Context
Synthetic compound
Check Digit Verification of cas no
The CAS Registry Mumber 51034-65-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,0,3 and 4 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 51034-65:
(7*5)+(6*1)+(5*0)+(4*3)+(3*4)+(2*6)+(1*5)=82
82 % 10 = 2
So 51034-65-2 is a valid CAS Registry Number.
51034-65-2Relevant articles and documents
Biological activity and phosphorylation of 2'-azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine
Kang, Shin Hong,Cho, Moo J.
, p. 1077 - 1088 (2007/10/03)
2'-Azido-2'-deoxyuridine and 2'-azido-2'-deoxycytidine were evaluated for their inhibitory activity against ribonucleotide reductase and for subsequent cell growth inhibition. Their mono- and di-phosphates were synthesized and their inhibitory activities against the reductase were also determined in a permeabilized cell system, along with the two nucleosides. The results of the present study identify the first phosphorylation step involved in the conversion of the two azidonucleosides to the corresponding diphosphates to be rate-limiting in the overall activation.
